Published online Jan 27, 2020. doi: 10.4254/wjh.v12.i1.6
Peer-review started: September 1, 2019
First decision: September 20, 2019
Revised: November 21, 2019
Accepted: November 29, 2019
Article in press: November 29, 2019
Published online: January 27, 2020
With the advances and clinical growth in liver transplantation over the last four decades the focus on expanding deceased donor organs has been in need of scientific research. In the past ten years several researchers have looked at the domain of machine perfusion as it applies to deceased donor livers. The following review focuses on the clinical trials and recent advances that will likely have the earliest entrance into the clinical arena.
Core tip: The processes involved in optimizing and expanding the deceased donor liver pool has led to the incorporation of machine perfusion technologies (as is similarly done in kidney transplantation). While none of the systems is approved for clinical use, several have gone through clinical trials. This summary provides an overview of those technologies that are likely to be used in clinical liver transplantation.