Human umbilical cord mesenchymal stem cells ameliorate liver metabolism in diabetic rats with metabolic-associated fatty liver disease

Table 1 Detailed information on the 70 key differential metabolites

Index1	Compound2	DM vs control		DM + hUC-MSCs vs DM
		Log2FC3	Type4	Log2FC3	Type4
MW0017091	Cholic acid	6.224	Up	-1.595	Down
MW0150760	Herbimycin	0.779	Up	-0.508	Down
MEDL01912	Succinic acid semialdehyde	0.259	Up	-0.401	Down
MW0109620	Ser-Leu	2.086	Up	-0.753	Down
MW0107510	Ile-Ser	0.564	Up	-1.202	Down
MW0108240	Methoxyacetic acid	1.678	Up	-1.124	Down
MEDL02562	Euscaphic acid	0.592	Up	-0.211	Down
MEDN1113	12-ketolithocholic acid	5.594	Up	-1.757	Down
MW0002133	2,3-dcpe hydrochloride	0.380	Up	-0.226	Down
MW0110455	Val-Val	0.590	Up	-0.369	Down
FDATN01012	Sodium cholate	2.152	Up	-1.258	Down
MW0124440	Ipriflavone	1.105	Up	-1.073	Down
MEDP2111	2’-hydroxy-4,4’,6’-trimethoxychalcone	0.444	Up	-0.389	Down
MW0052323	Diatoxanthin	0.396	Up	-0.164	Down
MEDP1440	Carnitine C5:0	1.640	Up	-0.819	Down
MW0105468	Ala-Ile	0.444	Up	-0.543	Down
MW0106195	Cyanophos	0.596	Up	-0.332	Down
MW0053910	Carnitine C6:0	1.386	Up	-1.118	Down
MW0010041	Vardenafil	1.858	Up	-1.180	Down
MW0055500	Levocarnitine propionate	2.527	Up	-0.808	Down
MEDP1665	Carnitine C3:0	2.093	Up	-0.950	Down
MW0123852	Erythrosine	1.865	Up	-0.943	Down
MW0063832	Tetrahydropersin	2.502	Up	-1.804	Down
MW0052943	Fulvestrant	2.365	Up	-2.123	Down
MW0006044	Anastrozole	2.351	Up	-2.422	Down
MW0122177	(6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol	0.793	Up	-0.745	Down
MW0014190	3-methylglutarylcarnitine	1.446	Up	-0.787	Down
MW0111511	D-fructofuranose	1.023	Up	-0.630	Down
MW0016403	Carnitine C5:1	0.826	Up	-0.826	Down
MEDP1381	Carnitine C20:2	1.525	Up	-0.847	Down
MEDP1524	Carnitine C16:2 isomer 1	0.950	Up	-0.671	Down
MEDP1434	Carnitine C4:DC	1.891	Up	-0.786	Down
MW0124143	Fluphenazine sulfoxide	0.284	Up	-0.098	Down
MW0145521	Arg-Thr-Leu-Ser-Asp	2.949	Up	-1.640	Down
MW0050103	1,2-dioleoyl-sn-glycerol	3.323	Up	-1.571	Down
ZINC149577	2-methoxycinnamic acid	3.876	Up	-0.198	Down
MW0159225	Val-Tyr-Pro-Glu-Leu	0.230	Up	-0.128	Down
MW0152568	Leu-Val-Phe-Ala-Ile	2.991	Up	-1.349	Down
MW0156774	Ser-His-Glu-Ala-Glu	0.955	Up	-0.383	Down
MW0156686	Ser-Asp-Ser-Gly-Val	0.537	Up	-0.767	Down
MW0126559	SIN-1 hydrochloride	0.337	Up	-0.547	Down
MW0105310	5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate	0.226	Up	-0.306	Down
MW0077514	TG(18:3(9Z,12Z,15Z)/14:0/20:5(5Z,8Z,11Z,14Z,17Z))	1.519	Up	-1.887	Down
MW0054746	Melleolide M	0.218	Up	-0.116	Down
MW0013853	3,7,11,15,23-pentaoxolanost-8-en-26-oic acid	4.610	Up	-1.426	Down
MW0106596	Enterobactin	1.636	Up	-0.400	Down
MW0009714	Salmeterol	0.206	Up	-0.227	Down
MW0007103	F-amidine (trifluoroacetate salt)	0.314	Up	-0.328	Down
MW0138813	Loxoprofen	0.605	Up	-0.436	Down
MW0168835	Beta-D-galactose	0.719	Up	-0.458	Down
MW0008605	N-[(4-hydroxy-3-methoxyphenyl)methyl]octanamide	0.290	Up	-0.260	Down
MW0016971	Celastrol	3.881	Up	-1.410	Down
MW0115265	Sedoheptulose 7-phosphate	0.817	Up	-0.783	Down
MW0141413	15(R)-17-phenyl trinor prostaglandin F 2alpha isopropyl ester	2.776	Up	-1.706	Down
MEDN0161	Guanosine 3’,5’-cyclic monophosphate	0.286	Up	-0.278	Down
MW0152475	Leu-Pro-Val-Leu-Glu	3.248	Up	-1.645	Down
MW0009539	Tyrphostin A25	0.322	Up	-0.294	Down
MW0152097	L-a-lysophosphatidylserine	2.594	Up	-1.768	Down
MW0128125	{3-[8-(1-{2,4-dihydroxyphenyl}-3-{3,4-dihydroxyphenyl}-2-hydroxypropyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-2-yl]phenyl}oxidanesulfonic acid	1.722	Up	-0.535	Down
MW0144016	8,12-diethyl-3-vinylbacteriochlorophyllide d	3.297	Up	-1.267	Down
MW0056727	Paeoniflorin	-2.291	Down	0.768	Up
MW0009853	Telmisartan	-0.497	Down	0.469	Up
MW0129372	{6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl}oxidanesulfonic acid	-1.983	Down	1.615	Up
MW0063704	Sulfaphenazole	-0.186	Down	0.168	Up
MEDN1575	Rhapontigenin	-1.550	Down	0.605	Up
MW0137976	Dihydromyricetin	-0.258	Down	0.214	Up
MW0158316	Trp-Val	-0.367	Down	0.177	Up
MW0118606	2-hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one	-0.156	Down	0.128	Up
MW0160275	D-Glycero-D-manno-heptose 1-phosphate	-0.559	Down	0.298	Up
MW0129025	{2-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]-3-hydroxy-6-methyl-5-oxooxan-4-yl}oxidanesulfonic acid	-1.801	Down	1.597	Up

¹Metabolite ID.

²Metabolite name.

³Logarithmic base 2 fold change.

⁴Regulation type (up- or downregulated metabolite).

Control group, n = 8; diabetes mellitus group, n = 6; diabetes mellitus + human umbilical cord mesenchymal stem cells group, n = 5. DM: Diabetes mellitus; hUC-MSCs: Human umbilical cord mesenchymal stem cells; FC: Fold change.