Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2025; 17(5): 101638
Published online May 26, 2025. doi: 10.4252/wjsc.v17.i5.101638
Circular RNAs inducing the osteogenic differentiation of dental mesenchymal stem cells via microRNA sponging
Yong-Song Jiang, Wei-Sheng Wei, Dao-Tao Xie, Gang Guo
Yong-Song Jiang, Wei-Sheng Wei, Department of Orthopedic, The Central Hospital of Yongzhou, Yongzhou 425000, Hunan Province, China
Yong-Song Jiang, Wei-Sheng Wei, Department of Orthopedic, Yongzhou Hospital Affiliated to University of South China, Yongzhou 425000, Hunan Province, China
Dao-Tao Xie, Gang Guo, Norxin International Technology Innovation Cooperation Platform, Xi’an 710032, Shaanxi Province, China
Co-first authors: Yong-Song Jiang and Wei-Sheng Wei.
Co-corresponding authors: Dao-Tao Xie and Gang Guo.
Author contributions: Jiang YS and Wei WS were contributors to the database search and preparing the paper draft, table, and figure, and revised the manuscript, they contributed equally to this manuscript as co-first authors; Xie DT and Guo G contributed to the conception and design of the work, corrected the draft and approved the revised manuscript, and they contributed equally to this manuscript as co-corresponding authors. All authors have read and approved the final manuscript. All authors agree to be accountable for all aspects of the work, ensuring integrity and accuracy.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dao-Tao Xie, MD, Professor, Norxin International Technology Innovation Cooperation Platform, Changle West Road, Xi’an 710032, Shaanxi Province, China. daotaoxie@gmail.com
Received: September 21, 2024
Revised: November 24, 2024
Accepted: April 14, 2025
Published online: May 26, 2025
Processing time: 246 Days and 16.5 Hours
Core Tip

Core Tip: Several circular RNAs were found to induce osteogenesis in dental mesenchymal stem cells through acting as microRNA sponges leading to eliminating the inhibitory impacts of microRNAs on downstream target genes. These circular RNAs can help identify new molecular elements that provide diagnostic biomarkers and/or therapeutic targets for treating bone-associated dental disorders.