Relationship between the expression of human telomerase reverse transcriptase gene and cell cycle regulators in gastric cancer and its significance

Table 1 Expression of hTRTmRNA in histologic pattern of gastric cancer and adjacent cancerous tissue

Groups	n	hTRTmRNA				Positive(%)	P
		(-)	(+)	(++)	(+++)
WD	26	5	12	7	2	80.8	0.067a
PD	22	3	11	8	0	83.4
Mucoid GC	5	3	1	1	0	40.0
Adjacent	53	45	6	2	0	15.1	< 0.01b

^a: comparison among groups of GC;

^b: comparison between adjacent cancerous tissue and GC. WD: well differentiated adenocarcinoma; PD: poorly differentiated adenocarcinoma.

Table 2 Expression of hTRT protein in histologic pattern of gastric cancer and adjacent cancerous tissue

Groups	n	hTRTmRNA				Positive(%)	P
		(-)	(+)	(++)	(+++)
WD	26	1	6	15	4	96.2	< 0.01a
PD	22	2	9	10	1	90.9
Mucoid GC	5	3	2	0	0	40.0
Adjacent	53	40	11	2	0	24.5	< 0.01b

^a: comparison among groups of GC;

^b: comparison between adjacent cancerous tissue and GC.

Table 3 Relationship between the expression of hTRTmRNA, hTRT protein and clinicopathological parameters in gastric cancer

Parameters	n	hTRTmRNA positive (%)	P	hTRT protein positive(%)	P
Gender
Male	42	35 (83.3)	0.309	39 (92.9)	0.180
Female	11	7(63.6)		8 (72.7)
Age(years)
<55	25	18 (72.0)	0.219	20 (80.0)	0.147
≥ 55	28	24 (85.7)		27 (96.4)
Tumor size(cm)
< 5	24	20 (83.3)	0.735	22 (91.7)	0.678
≥ 5	29	22 (75.9)		25 (86.2)
Tumor location
Cardia	26	23 (88.5)	0.128	24 (92.3)	0.529
Body	16	10 (62.5)		13 (81.3)
Antrum	11	9 (81.8)		10 (90.9)
Lymph node metastasis
Absent	25	18 (72.0)	0.219	20 (80.0)	0.089
Present	28	24 (85.7)		27 (96.4)
Invasion depth
Not invading serosa	8	7(87.5)	0.879	7 (87.5)	1.000
Invading serosa	45	35 (77.8)		40 (88.9)
Clinical stage
I and II	47	37 (78.7)	1.000	41 (87.2)	0.806
III and IV	6	5 (83.3)		6 (100.0)