The effect of famotidine on gastroesophageal and duodeno-gastro-esophageal refluxes in critically ill patients

Table 1 Acid reflux comparison before and after famotidine administration

	Before administration	After administration	P value
Reflux frequency	81.60 ± 110.57 (49.50)	39.50 ± 59.44 (22.00)	0.059
Frequency of long reflux (> 5 min)	13.90 ± 13.08 (9.50)	7.60 ± 9.79 (6.00)	0.052
Longest reflux time (min)	34.80 ± 64.12 (12.00)	9.30 ± 10.20 (7.50)	0.037
pH < 4 reflux time (min)	146.80 ± 293.46 (34.50)	27.10 ± 45.68 (14.00)	0.005
pH < 4 fraction time (%)	18.43 ± 19.64 (11.43)	0.44 ± 0.55 (0.18)	0.005

Table 2 Bile reflux comparison before and after famotidine administration

	Before administration	After administration	P value
Reflux frequency	37.20 ± 19.00 (34.50)	14.30 ± 12.04 (11.50)	0.007
Frequency of long reflux (> 5 min)	13.30 ± 5.93 (13.50)	5.40 ± 7.88 (2.00)	0.024
Longest reflux time (min)	111.20 ± 142.42 (18.00)	17.90 ± 30.63 (5.50)	0.005
Absorption > 0.14 reflux time (min)	308.00 ± 413.02 (49.50)	32.60 ± 49.40 (11.00)	0.007
Absorption > 0.14 fraction time (%)	26.00 ± 27.33 (15.30)	0.64 ± 10.39 (0.29)	0.005