Clinical Research
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 2003; 9(2): 356-358
Published online Feb 15, 2003. doi: 10.3748/wjg.v9.i2.356
The effect of famotidine on gastroesophageal and duodeno-gastro-esophageal refluxes in critically ill patients
Ying Xin, Ning Dai, Lan Zhao, Jian-Guo Wang, Jian-Ming Si
Ying Xin, Ning Dai, Lan Zhao, Jian-Guo Wang, Department of Gastroenterology, Sir Run Run Shaw Hospital, Hangzhou 310016, Zhejiang Province, China
Jian-Ming Si, Zhejiang University, medical college, Hangzhou 310031, Zhejiang Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr.Ying Xin, Department of Gastroenterology, Sir Run Run Shaw Hospital, Hangzhou 310016, Zhejiang Province, China. xinying20012001@yahoo.com.cn
Telephone: +86-571-86994122
Received: June 23, 2002
Revised: July 4, 2002
Accepted: July 25, 2002
Published online: February 15, 2003
Abstract

AIM: To investigate the effect of famotidine on gastroesophageal reflux (GER) and duodeno-gastro-esophageal reflux (DGER) and to explore it's possible mechanisms. To identify the relevant factors of the reflux.

METHODS: Ninteen critically ill patients were consecutively enrolled in the study. Dynamic 24 h monitoring of GER and DGER before and after administration of famotidine was performed. The parameters of gastric residual volume,multiple organ disorder syndrome (MODS) score, acute physiology and chronic health evaluation II (APACHE II) score and PEEP were recorded. Paired t test; Wilcoxon signed ranks test and Univariate analysis with Spearman's rank correlation were applied to analyse the data.

RESULTS: Statistical significance of longest acid reflux, reflux time of pH < 4 and fraction time of acid reflux was observed in ten critically ill patients before and after administration. P value is 0.037, 0.005, 0.005 respectively. Significance change of all bile reflux parameters was observed before and after administration. P value is 0.007, 0.024, 0.005, 0.007, 0.005. GER has positive correlation with APACHE II score and gastric residual volume with correlation coefficient of 0.720, 0.932 respectively.

CONCLUSION: GER and DGER are much improved after the administration of famotidine. GER is correlated with APACHE II score and gastric residual volume.

Keywords: $[Keywords]