Role of NF-κB in multiple organ dysfunction during acute obstructive cholangitis

Table 1 Arterial blood gas analyses in three groups animals

Parameter	Early Phase (6 h)			Late Phase (48 h)
	AOC	BDL	SO	AOC	BDL	SO
pH	7.52 ± 0.01a	7.46 ± 0.02	7.45 ± 0.02	7.33 ± 0.07a	7.67 ± 0.04	7.46 ± 0.03
pCO2 (mmHg)	33.9 ± 0.95a	38.1 ± 0.89	38.9 ± 0.94	40.4 ± 4.23	37.8 ± 3.51	37.5 ± 0.72
HCO3- (mmol/L)	26.6 ± 0.63	28.3 ± 0.86	27.8 ± 1.04	20.1 ± 1.57a	26.7 ± 1.45	27.82 ± 1.25
pO2 (mmHg)	105.1 ± 6.4	108.3 ± 4.2	106.5 ± 5.8	67.3 ± 6.9a	104.7 ± 5.3	110.7 ± 4.6

^aP < 0.05, vs other groups.

Table 2 Biochemical parameters in three groups animals

Parameter	Early Phase (6 h)			Late Phase (48 h)
	AOC	BDL	AOC	BDL	AOC	BDL
LDH (nkat·L-1)	13632.7 ± 891.8a	4107.4 ± 951.9	3655.7 ± 576.8	16359.9 ± 2278.8a	6793 ± 885.1c	3742.4 ± 570.1
ALT (nkat·L-1)	2213.8 ± 391.7a	343.4 ± 103.3	311.7 ± 91.7	5796.2 ± 941.9a	955.2 ± 175c	288.4 ± 75
BUN (mg/dl)	16.3 ± 13.3	12.9 ± 2.8	11.8 ± 2.2	55.7 ± 15.3a	16.7 ± 4.6	12.5 ± 2.14
Cr (mg/dl)	0.48 ± 0.03	0.42 ± 0.02	0.41 ± 0.03	0.72 ± 0.06a	0.51 ± 0.03	0.47 ± 0.03

^aP < 0.05, vs other groups.

^cP < 0.05, vs SO group.

Table 3 TNF-α and IL-6 levels in plasma (n = 7)

Groups	TNF-α (ng·L-1)		IL-6 (ng·L-1)
	6 h	48 h	6 h	48 h
AOC	235 ± 39.23a	429 ± 56.62a	253 ± 23.41a	562 ± 57.58a
BDL	73 ± 11.52	139 ± 16.21c	113 ± 21.39	227 ± 43.02c
SO	72 ± 12.45	74 ± 10.53	109 ± 18.37	113 ± 19.81

^aP < 0.05, vs other two groups.

^cP < 0.05, vs SO group.