Brief Reports
Copyright ©The Author(s) 2001.
World J Gastroenterol. Feb 15, 2001; 7(1): 93-97
Published online Feb 15, 2001. doi: 10.3748/wjg.v7.i1.93
Table 1 Inhibitory effect of BAM on the growth of human colorectal xenografts in nude mice*
DrugTumorNo. of miceDose (mg/kg)Tumor weight (g) x-± sTumor growth inhibition (%)
61.300 ± 0.620
HT-296100.138 ± 0.06489b
6150.098 ± 0.07492b
BAM
Hce-869351.501 ± 1.445
5100.154 ± 0.12590b
5150.122 ± 0.15492b
Table 2 Inhibitory effect of BAM, MMC and 5-Fu on the growth and tumor cell mitosis of human colon cancer HT-29 xenografts in nude mice*
DrugDose** (mg/kg)No. of miceTumor weight (g) x-± sInhibitory rate (%)Necrotic ratio of umors(%)Mitotic figures△△
x-± s(%)
Control50.804 ± 0.17335b104 ± 12100
BAM1050.148 ± 0.059826741 ± 439b
MMC150.376 ± 0.17453a43b107 ± 12103
5-FU2750.707 ± 0.16812b35b130 ± 17130
Table 3 Inhibitory effect of BAM, MMC and 5-FU on the growth of CT-26 tumor at the cecum and s.c site in mice*
Exp.DrugDose** (mg/kg)No. of mices.c. tumor
Cecal tumor
Tumor weight (g) x-± sInhibitory rate (%)Tumor weight (g) x-± sInhibitory rate (%)
IControl90.854 ± 0.1510.557 ± 0.112
BAM1090.101 ± 0.05488b0.005 ± 0.01099b
MMC180.311 ± 0.105640.159 ± 0.04371
5-FU2780.459 ± 0.118460.310 ± 0.14844
IIControl60.900 ± 0.3960.740 ± 0.446
BAM1060.105 ± 0.08888b0.011 ± 0.01999b
MMC150.674 ± 0.270250.159 ± 0.51078
5-FU2760.657 ± 0.322270.434 ± 0.25541
Table 4 Bone marrow nucleated cells in mice bearing CT-26 treated by BAM, 5-FU and MMC
Exp.DrugDose** (mg/kg)No. of miceNucleated cells (106/femur)
x-± s%
IControl613 ± 3100
BAM10613 ± 3100
MMC157 ± 254b
5-FU2767 ± 254b
IIControl912 ± 3100
BAM10912 ± 2100
MMC183 ± 125b
5-FU2784 ± 133b