Relationship of lmp2 and DR3 genes with susceptibility to type I diabetes mellitus in south China Han population

Table 1 Comparison of frequencies of lmp2 genotypes and DR3 gene between I-DM patients and controls in random subjects

	n	DR3	lmp2
			R/R	R/H	H/H
1-DM	68	32(0.47)a	29(0.43)b	36(0.53)c	3(0.04)
Controls	71	15(0.21)	43(0.61)	20(0.28)	8(0.11)

Compared with controls:

^ax² = 10.44, ψ = 3.32, P < 0.0 05;

^bx² = 4.47, ψ= 0.48, P < 0.05;

^cx² = 8.86, ψ = 2.87, P < 0.005.

Table 2 Frequencies of lmp2 genotypes compared between I-DM patients and controls in DR3-matched subjects

	Positive DR3		Negative DR3
	1-DM (n = 32)	Controls (n = 15)	1-DM (n = 36)	Controls (n = 56)
R/R	15(0.47)a	13(0.87)	14(0.39)	30(0.54)
R/H	15(0.47)b	2(0.13)	21(0.58)c	18(0.32)
H/H	2(0.06)	0(0.00)	1(0.03)	8(0.14)

Compared with controls:

^ax² = 7.50, ψ = 0.14, P < 0.01;

^bx² = 4.98, ψ = 5.74, P < 0.05;

^cx² = 6.15, ψ = 2.96, P < 0.01.

Table 3 Frequencies of lmp2 genotypes and DR3 gene compared amon g different age groups of diabetic onset

	n	DR3		lmp2
		Positive	Negative	R/R	R/H	H/H
Group A	23	16(70%)	7(30%)	11(48%)	10(43%)	2(9%)
Group B	26	11(42%)	15(58%)	8(31%)	17(65%)	1(4%)
Group C	19	5(26%)	14(74%)	10(53%)	9(47%)	0

Difference of DR3 frequency among different age groups of diabetic onset was χ² = 8.19, rp = 0.33, P < 0.05, lmp2 was χ² = 4.53, P > 0.05.