Retrospective Study
Copyright ©The Author(s) 2022.
World J Gastroenterol. Jul 28, 2022; 28(28): 3682-3694
Published online Jul 28, 2022. doi: 10.3748/wjg.v28.i28.3682
Table 1 Demographic and clinical data of patients
Variables
Total
H. pylori+
H. pylori-
P value
Patients, n1015854161
Age in year, median (IQR)11 (9-13)11 (9-13)9 (6-12)< 0.001a
Sex, n (%)
Female411 (40.49)346 (40.52)65 (40.37)
Male604 (59.51)508 (59.48)96 (59.63)0.973
Endoscopic pattern, n (%)
Esophagitis28 (2.76)23 (2.69)5 (3.11)0.975
Superficial gastritis331 (32.61)255 (29.86)76 (47.20)< 0.001b
Superficial gastritis with erosion236 (23.25)200 (23.42)36 (22.36)0.77
Superficial gastritis with bile reflux295 (29.06)251 (29.39)44 (27.33)0.597
Antral nodularity135 (13.30)131 (15.34)4 (2.48)< 0.001b
Peptic ulcer90 (8.87)80 (9.37)10 (6.21)0.196
Atrophic gastritis18 (1.77)17 (1.99)1 (0.62)0.378
Clinical diagnosis, n (%)
Esophagitis28 (2.76)23 (2.69)5 (3.11)0.975
Non atrophic gastritis997 (98.23)837 (98.01)160 (99.38)0.378
Atrophic gastritis18 (1.77)17 (1.99)1 (0.62)0.378
Gastric ulcer18 (1.77)16 (1.87)2 (1.24)0.817
Duodenal ulcer72 (7.09)64 (7.49)8 (4.97)0.252
Table 2 Helicobacter pylori infection status in different age groups
Age group
Sex, n (male/female)
H. pylori+, n (%)
H. pylori-, n (%)
1-454 (29/25)22 (40.74)32 (59.26)
5-8199 (111/88)156 (78.39)a43 (21.61)
9-12435 (286/149)383 (88.05)a,b52 (11.95)
13-18327 (178/149)293 (89.60)a,b34 (10.40)
Total1015 (604/411)854 (84.14)161 (15.86)
Table 3 Precancerous lesions in the gastric mucosa in children and adolescents
Age groupH. pylori+
SubtotalH. pylori-
Subtotal
n
Atrophy
IM
Dysplasia
n
Atrophy
IM
Dysplasia
1-4221113320000
5-81564419430000
9-1238363615520000
13-1829363110341001
Total85437 (4.33%)a1611 (0.62%)
Table 4 Comparison of active inflammation between Helicobacter pylori-positive and -negative patients
Age groupH. pylori+
H. pylori-
n
Active inflammation
Non-active inflammation
n
Active inflammation
Non-active inflammation
1-4223 (13.64)19 (86.36)322 (6.25)30 (93.75)
5-815623 (14.74)a133 (85.26)431 (2.33)42 (97.67)
9-1238352 (13.58)b331 (86.42)522 (3.85)50 (96.15)
13-1829359 (20.14)c234 (79.86)341 (2.94)33 (97.06)
Total854137 (16.04)d717 (83.96)1616 (3.73)155 (96.27)
Table 5 Degree of neutrophil granulocyte infiltration in Helicobacter pylori-positive and -negative patients
Age group
H. pylori+
H. pylori+
Z
P value
n
Absent
Mild
Moderate
n
Absent
Mild
Moderate
1-42219 (86.36)3 (13.64)0 (0)3230 (93.75)2 (6.25)0 (0)0.9120.362
5-8156133 (85.26)21 (13.46)2 (1.28)4342 (97.67)1 (2.33)0 (0)2.2120.027a
9-12383331 (86.42)44 (11.49)8 (2.09)5250 (96.15)2 (3.85)0 (0)2.0090.045b
13-18293234 (79.86)48 (16.38)11 (3.76)3433 (97.06)1 (2.94)0 (0)2.4560.014c
Total854717 (83.96)116 (13.58)21 (2.46)161155 (96.27)6 (3.73)0 (0)4.319< 0.001d
Table 6 Degree of lymphocyte infiltration in Helicobacter pylori-positive and -negative patients
Age group
H. pylori+
H. pylori-
Z
P value
n
Mild
Moderate
Marked
n
Mild
Moderate
Marked
1-42210 (45.45)11 (50)1 (4.55)3217 (53.12)14 (43.75)1 ( 3.13)0.570.569
5-815667 (42.95)75 (48.08)14 (8.97)4324 (55.81)18 (41.86)1 (2.33)1.7370.082
9-12383161 (42.04)195 (50.91)27 (7.05)5231 (59.62)20 (38.46)1 (1.92)2.5390.01a
13-18293112 (38.23)151 (51.54)30 (10.24)3419 (55.88)14 (41.18)1 (2.94)2.1640.03b
Total854350 (40.98)432 (50.59)72 (8.43)16191 (56.52)66 (40.99)4 (2.48)3.997< 0.00c