Characterizing the composition of intestinal microflora by 16S rRNA gene sequencing

Table 1 Clinical characteristics of patients at baseline

Characteristic	Normal mucosa	Advanced CRA	P value
Age in yr	58.9 ± 7.2	62.9 ± 9.9	0.058
Gender
Male	18	28	0.448
Female	18	20
BMI	25.2 ± 3.6	26.3 ± 3.9	0.229
Site
Right colon	9	10	0.651
Left colon	27	39

BMI: Body mass index; CRA: Colorectal adenoma.

Table 2 Statistics of alpha diversity

α	Normal mucosa	Advanced CRA	Adjacent normal mucosa	P value
Sobs	271 ± 90	215 ± 86	253 ± 91	< 0.001a
Chao	301 ± 102	249 ± 104	291 ± 95	0.008
ACE	296 ± 102	253 ± 105	291 ± 93	0.020
Shannon	2.56 ± 0.68	2.30 ± 0.71	2.68 ± 0.72	0.028
Simpson	0.21 ± 0.12	0.26 ± 0.11	0.20 ± 0.12	0.031

ACE: Index used to estimate the number of OTU in the community; CRA: Colorectal adenoma.

^aP < 0.001: P = 0.00076.