Copyright ©The Author(s) 2018.
World J Gastroenterol. Nov 28, 2018; 24(44): 4962-4973
Published online Nov 28, 2018. doi: 10.3748/wjg.v24.i44.4962
Table 1 Hepatitis C virus-derived mechanisms underlying dendritic cell impairment
HCV proteinTarget cellsFunctional changeMechanismRef.
HCV core and NS3mDCsImpaired maturationIncreased IL-10 and decreased IL-12 production[64]
Impaired T-cell stimulation
E2mDCsAlter DC migratory behaviorInteracts with CD81[120]
pDCsInhibited maturation[121]
Impaired activation
Decreased IFN-α production
E2 andNS3mDCsImpaired IFN-λ productionNot shown[113]
NS4mDCsTh1 cytokine reductionNot shown[122]
T-cell stimulatory impairment
NS5AmDCsIncreased IL-8 productionNot shown[123]
Impaired interferon signalingInfluence the phosphorylation of STAT1 and STAT2