Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2018; 24(44): 4962-4973
Published online Nov 28, 2018. doi: 10.3748/wjg.v24.i44.4962
Mononuclear phagocyte system in hepatitis C virus infection
Yu Yang, Zheng-Kun Tu, Xing-Kai Liu, Ping Zhang
Yu Yang, Xing-Kai Liu, Ping Zhang, Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Zheng-Kun Tu, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China
Author contributions: Liu XK collected the information; Yang Y wrote the paper; Tu ZK and Zhang P revised the paper.
Conflict-of-interest statement: No potential conflicts of interest and no financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author to: Ping Zhang, MD, Chief Doctor, Professor, Surgeon, Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun 130021, Jilin Province, China.
Telephone: +86-431-81875168 Fax: +86-431-81875168
Received: September 8, 2018
Peer-review started: September 10, 2018
First decision: October 24, 2018
Revised: October 30, 2018
Accepted: November 7, 2018
Article in press: November 8, 2018
Published online: November 28, 2018
Core Tip

Core tip: Hepatitis C virus (HCV) infection is efficient to develop into chronic infection. Innate immune system can shape the acquired immune response, which can eradicate HCV directly. As the main component of innate immunity, the mononuclear phagocyte system (MPS) plays a vital role in HCV infection. In this review, we discuss the interaction between the HCV and MPS. MPS can detect HCV to promote virus eradication, and HCV can shape the MPS to facilitate HCV persistence. We hope that this review will enable us to better understand HCV infection.