Published online Nov 28, 2018. doi: 10.3748/wjg.v24.i44.4962
Peer-review started: September 10, 2018
First decision: October 24, 2018
Revised: October 30, 2018
Accepted: November 7, 2018
Article in press: November 8, 2018
Published online: November 28, 2018
Core tip: Hepatitis C virus (HCV) infection is efficient to develop into chronic infection. Innate immune system can shape the acquired immune response, which can eradicate HCV directly. As the main component of innate immunity, the mononuclear phagocyte system (MPS) plays a vital role in HCV infection. In this review, we discuss the interaction between the HCV and MPS. MPS can detect HCV to promote virus eradication, and HCV can shape the MPS to facilitate HCV persistence. We hope that this review will enable us to better understand HCV infection.