Soares-Mota M, Silva TA, Gomes LM, Pinto MA, Mendonça LM, Farias MLF, Nunes T, Ramalho A, Zaltman C. High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test. World J Gastroenterol 2015; 21(5): 1614-1620 [PMID: 25663781 DOI: 10.3748/wjg.v21.i5.1614]
Corresponding Author of This Article
Dr. Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro 21941-913, Brazil. msoares@nutricao.ufrj.br
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
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Table 3 Relationship between normal and low serum retinol levels and negative and positive relative dose response test results in Crohn's disease patients and controls
Serum retinol levels
RDR test
Negative
Positive
CD
CT
CD
CT
Normal
22
28
5
0
Low
2
1
9
4
Total
24
29
14
4
Table 4 Body composition parameters, vitamin A intake, disease duration and clinical characteristics of interest in Crohn's disease patients, according to serum retinol level
Parameters
< 1.05 μmol/L(n = 11)
≥1.05 μmol/L(n = 27)
P value
BMI (kg/m2)
21.69 ± 2.74
25.65 ± 5.48
0.029
Weight (kg)
58.75 ± 9.46
68.96 + 15.59
0.051
Body fat (%)
26.13 ± 10.32
33.27 ± 11.68
0.131
LM (kg)
38.66 ± 8.35
43.04 ± 10.03
0.272
BMC (kg)
2.21 ± 0.55
2.44 ± 0.50
0.273
Body fat (kg)
13.22 ± 5.43
22.53 ± 11.28
0.032
Vitamin A intake (μg/d)
1125.7
1163.9
0.561
Disease duration (yr)
6.73 ± 7.89
2.41 ± 2.94
0.164
Bowel resection
7 (63)
13 (48)
0.386
Ileal resection
2 (18)
3 (11)
0.956
Ileal involvement
10 (90)
20 (74)
0.430
Active disease (HB index)
3 (27)
1 (4)
0.330
High CRP levels
2 (18)
9 (33)
0.430
Low HB levels
1 (9)
5 (18)
0.345
Citation: Soares-Mota M, Silva TA, Gomes LM, Pinto MA, Mendonça LM, Farias MLF, Nunes T, Ramalho A, Zaltman C. High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test. World J Gastroenterol 2015; 21(5): 1614-1620