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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1614-1620
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1614
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1614
High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test
Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil
Tianny A Silva, Luanda M Gomes, Marco AS Pinto, Laura MC Mendonça, Maria Lúcia F Farias, Andrea Ramalho, Cyrla Zaltman, Departamento de Clínica Médica, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil
Tiago Nunes, Nutrition and Immunology Chair, ZIEL Research Center for Nutrition and Food Sciences, Technical University of München, Freising-Weihenstephan, 80333 München, Germany
Author contributions: Soares-Mota M and Zaltman C were involved in the study design, manuscript writing and provided financial support for this work; Ramalho A contributed to the study design and critically reviewed the manuscript; Silva TA collected all human samples and performed all physical evaluations; Gomes LM was involved in data collection and in the nutritional assessment of patients; Pinto MAS performed the statistical analysis; Mendonça LMC and Farias MLF were responsible for the body composition and DEXA measurements; Nunes T was involved in final manuscript writing and editing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro 21941-913, Brazil. msoares@nutricao.ufrj.br
Telephone: +55-21-2562-2326 Fax: +55-21-22421637
Received: August 16, 2014
Peer-review started: August 16, 2014
First decision: September 15, 2014
Revised: October 1, 2014
Accepted: October 21, 2014
Article in press: January 23, 2015
Published online: February 7, 2015
Peer-review started: August 16, 2014
First decision: September 15, 2014
Revised: October 1, 2014
Accepted: October 21, 2014
Article in press: January 23, 2015
Published online: February 7, 2015
Core Tip
Core tip: In this study, a higher prevalence of vitamin A deficiency was detected in Crohn’s disease (CD) patients compared with healthy controls by measuring serum retinol levels and the relative dose-response test. According to the relative dose-response test, almost 40% of the CD patients had inadequate hepatic vitamin A stores, which was three times the value found in healthy controls. CD Patients with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency. There was no association between vitamin A deficiency and its dietary intake, ileal location, presence of disease activity and prior bowel resections.