Soares-Mota M, Silva TA, Gomes LM, Pinto MA, Mendonça LM, Farias MLF, Nunes T, Ramalho A, Zaltman C. High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test. World J Gastroenterol 2015; 21(5): 1614-1620 [PMID: 25663781 DOI: 10.3748/wjg.v21.i5.1614]
Corresponding Author of This Article
Dr. Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro 21941-913, Brazil. msoares@nutricao.ufrj.br
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Feb 7, 2015; 21(5): 1614-1620 Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1614
High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test
Márcia Soares-Mota, Tianny A Silva, Luanda M Gomes, Marco AS Pinto, Laura MC Mendonça, Maria Lúcia F Farias, Tiago Nunes, Andrea Ramalho, Cyrla Zaltman
Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil
Tianny A Silva, Luanda M Gomes, Marco AS Pinto, Laura MC Mendonça, Maria Lúcia F Farias, Andrea Ramalho, Cyrla Zaltman, Departamento de Clínica Médica, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil
Tiago Nunes, Nutrition and Immunology Chair, ZIEL Research Center for Nutrition and Food Sciences, Technical University of München, Freising-Weihenstephan, 80333 München, Germany
Author contributions: Soares-Mota M and Zaltman C were involved in the study design, manuscript writing and provided financial support for this work; Ramalho A contributed to the study design and critically reviewed the manuscript; Silva TA collected all human samples and performed all physical evaluations; Gomes LM was involved in data collection and in the nutritional assessment of patients; Pinto MAS performed the statistical analysis; Mendonça LMC and Farias MLF were responsible for the body composition and DEXA measurements; Nunes T was involved in final manuscript writing and editing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Márcia Soares-Mota, Instituto de Nutrição Josué de Castro, Federal University of Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro 21941-913, Brazil. msoares@nutricao.ufrj.br
Telephone: +55-21-2562-2326 Fax: +55-21-22421637
Received: August 16, 2014 Peer-review started: August 16, 2014 First decision: September 15, 2014 Revised: October 1, 2014 Accepted: October 21, 2014 Article in press: January 23, 2015 Published online: February 7, 2015
Abstract
AIM: To assess the vitamin A status of patients with Crohn’s disease (CD) by evaluating serum retinol levels and the relative dose response (RDR) test (liver retinol stores).
METHODS: Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores. Body composition was performed by densitometry by dual-energy X-ray absorptiometry. Vitamin A dietary intake was assessed from a semi-quantitative food frequency questionnaire.
RESULTS: This study included 38 CD patients and 33 controls. Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls (P < 0.005). The RDR test was positive in 37% of CD patients vs 12% in controls, which indicated inadequate hepatic vitamin A stores (P < 0.005). Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency. There was no association between vitamin A deficiency and its dietary intake, ileal location, presence of disease activity and prior bowel resections.
CONCLUSION: Patients with CD have higher prevalence of vitamin A deficiency, as assessed by two independent methods.
Core tip: In this study, a higher prevalence of vitamin A deficiency was detected in Crohn’s disease (CD) patients compared with healthy controls by measuring serum retinol levels and the relative dose-response test. According to the relative dose-response test, almost 40% of the CD patients had inadequate hepatic vitamin A stores, which was three times the value found in healthy controls. CD Patients with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency. There was no association between vitamin A deficiency and its dietary intake, ileal location, presence of disease activity and prior bowel resections.
