No association of G-protein beta polypeptide 3 polymorphism with irritable bowel syndrome: Evidence from a meta-analysis

Table 1 Characteristics of individual studies in the meta-analysis

Ref.	Year	Country	IBS/controls	Diagnosis criteria	HWE of control
Kim et al[15]	2012	South Korea	60/434	Rome III	0.850
Park et al[10]	2012	South Korea	72/148	Rome III	0.411
Saito et al[18]	2012	United States	385/262	Rome II	0.154
Lee et al[5]	2010	South Korea	94/88	Rome III	0.010
Markoutsaki et al[6]	2011	Greece	124/238	Rome III	0.825
de Vries et al[9]	2009	Netherlands	136/373	Rome II	0.099
Andresen et al[14]	2006	United States	214/152	Rome II	0.514

IBS: Irritable bowel syndrome; HWE: Hardy-Weinberg equilibrium.

Table 2 Pooled results of GNB3 C825T polymorphism with irritable bowel syndrome risk

GNbeta3 C825T	Pvalue	OR (95%CI)	I2	Pheterogeneity	Begg’s test	Egger’s test
CC vs TT	0.392	1.12 (0.86-1.45)	43.4	0.102	0.352	0.133
Caucasian	0.177	1.26 (0.90-1.76)	57.8	0.068
Asian	0.750	0.93 (0.61-1.42)	11.7	0.322
CC + CT vs TT	0.205	1.17 (0.92-1.49)	39.9	0.126	0.308	0.230
Caucasian	0.364	1.16 (0.84-1.60)	58.0	0.067
Asian	0.374	1.18 (0.82-1.70)	29.6	0.241
TT + CT vs CC	0.347	0.93 (0.80-1.08)	17.5	0.296	1.000	0.710
Caucasian	0.169	0.89 (0.75-1.05)	10.3	0.342
Asian	0.456	1.14 (0.80-1.65)	16.0	0.304
C vs T	0.157	1.08 (0.97-1.21)	24.8	0.240	0.756	0.548
Caucasian	0.089	1.13 (0.98-1.29)	43.7	0.149
Asian	0.982	1.00 (0.82-1.22)	0.0	0.417