Meta-Analysis
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World J Gastroenterol. May 28, 2014; 20(20): 6345-6352
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6345
No association of G-protein beta polypeptide 3 polymorphism with irritable bowel syndrome: Evidence from a meta-analysis
Zhi-Gang Pan, Chen Xiao, Dong-Xing Su
Zhi-Gang Pan, Chen Xiao, Dong-Xing Su, Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, Nanning 530031, Guangxi Zhuang Autonomous Region, China
Author contributions: Su DX and Pan ZG conceived the study and implemented the final draft of the manuscript; Pan ZG and Xiao C performed the statistical analysis and wrote the paper; Pan ZG and Xiao C searched the studies and extracted the data; all authors read and approved the final manuscript.
Correspondence to: Dr. Dong-Xing Su, Department of Gastroenterology, the Third Affiliated Hospital of Guangxi Medical University, 13 Dancun Road, Nanning 530031, Guangxi Zhuang Autonomous Region, China. 553851548@qq.com
Telephone: +86-771-2246364  Fax: +86-771-2246523
Received: November 23, 2013
Revised: December 15, 2013
Accepted: January 14, 2014
Published online: May 28, 2014
Abstract

AIM: To clarify the associations between G-protein beta polypeptide 3 (GNB3) C825T polymorphism and risk of the irritable bowel syndrome (IBS) by a meta-analysis.

METHODS: We searched relevant studies in PubMed, EMBASE, CNKI, Google Scholar, Ovid and Cochrane library prior to October 2013. The strengths of the associations between GNB3 C825T polymorphism and IBS risk were estimated by odds ratios (ORs) with 95% confidence interval (CIs).

RESULTS: We identified seven case-control studies with 1085 IBS cases and 1695 controls for the analysis. We found no significantly associations of GNB3 C825T polymorphism with IBS risk in the overall population (CC vs TT, OR = 1.12, 95%CI: 0.86-1.45; CC + CT vs TT, OR = 1.17, 95%CI: 0.92-1.49; TT + CT vs CC, OR = 0.93, 95%CI: 0.80-1.08; C vs T, OR = 1.08, 95%CI: 0.97-1.21). Subgroup analysis did not reveal significant associations either in Asian population or Caucasian population. The pooled results of four studies fail to show associations of GNB3 C825T polymorphism with subtypes of IBS (constipation-dominant type, diarrhea-dominant type and mixed type).

CONCLUSION: The present study suggests no associations of GNB3 C825T polymorphism with IBS risk.

Keywords: Irritable bowel syndrome, G-protein beta polypeptide 3, Polymorphisms, Meta-analysis

Core tip: G-protein beta polypeptide 3 (GNB3) polymorphisms have been identified as an independent risk factor causally associated with functional gastrointestinal disorder and receive extensive interest. However, their association with irritable bowel syndrome (IBS) remains controversial. In the present paper, the authors combined the data from seven case-control studies with 1085 IBS cases and 1695 controls, and found that there were associations between GNB3 C825T polymorphism and IBS risk in the overall population; subgroup analysis did not reveal significant associations either in Asian population or Caucasian population. In regard to the subtypes of IBS (constipation-dominant type, diarrhea-dominant type and mixed type), no associations were found either.