Fujita M, Nakamura Y, Kasashima S, Furukawa M, Misaka R, Nagahara H. Risk factors associated with Barrett’s epithelial dysplasia. World J Gastroenterol 2014; 20(15): 4353-4361 [PMID: 24764673 DOI: 10.3748/wjg.v20.i15.4353]
Corresponding Author of This Article
Hikaru Nagahara, Professor, Department of Gastroenterology, Aoyama Hospital, Tokyo Women’s Medical University, 2-7-13 Kitaaoyama, Minato-ku, Tokyo 1070061, Japan. nagahara.hikaru@twmu.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Research Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 21, 2014; 20(15): 4353-4361 Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4353
Table 1 Characterization of the three types of Barrett’s esophagus
Specialized columnar
P value
Epithelium type
Junctional type
Gastric fundic type
(n = 65)
(n = 38)
(n = 48)
Sex
52/13
10/28
25/23
0.005
Age (yr)
62.9 ± 10.6
65.0 ± 8.2
58.8 ± 11.9
0.07
Dysplasia
20/65 (30.8%)
3/38 (7.9%)
2/48 (4.2%)
0.003
Table 2 Univariate analysis of variables associated with Barrett’s epithelial dysplasia
Normal (n = 45)
Dysplasia (n = 20)
P value
OR
95%CI
Sex (male/female)
Dec-33
19/1
0.073
0.145
0.017-1.202
Age (yr)
65.0 ± 9.8
64.2 ± 11.3
0.730
0.991
0.940-1.044
Length of BE (SSBE/LSBE)
Feb-43
18/2
0.402
2.389
0.312-18.294
H. pylori infection rate
34/9 (2)
7/12 (1)
0.0021
0.154
0.047-0.506
p53 positive rate
4/41
13/7
< 0.0011
19.036
4.800-75.499
Body weight (kg)
61.0 ± 9.7
68.2 ± 10.6
0.019
1.081
1.013-1.154
BMI (kg/m2)
23.1 ± 2.8
23.7 ± 3.2
0.451
1.074
0.891-1.295
Waist circumference (cm)
86.9 ± 7.9
88.4 ± 9.0
0.585
1.022
0.945-1.105
GERD
19/26
9/11
0.835
1.120
0.387-3.235
Hypertension (BP > 130/85)
29/14 (2)
9/10 (1)
0.094
0.395
0.133-1.172
Systolic BP (mmHg)
127 ± 16
121 ± 16
0.264
0.980
0.946-1.015
Diastolic BP (mmHg)
76 ± 10
69 ± 8
0.009
0.907
0.843-0.976
Diabetes
14/25 (6)
10/9 (1)
0.188
2.071
0.701-6.124
Fasting blood glucose (mg/dL)
118 ± 32
111 ± 19
0.447
0.992
0.971-1.013
HbA1c (%)
5.6 ± 1.0
5.5 ± 0.7
0.804
0.919
0.470-1.798
Dyslipidemia
24/19 (2)
11/8 (1)
0.322
0.576
0.193-1.715
TG (mg/dL)
144 ± 58
139 ± 98
0.807
0.999
0.991-1.007
TC (mg/dL)
202 ± 30
189 ± 33
0.141
0.987
0.969-1.005
HDL-C (mg/dL)
55 ± 13
53 ± 9
0.850
0.996
0.950-1.043
LDL-C (mg/dL)
118 ± 26
107 ± 30
0.152
0.985
0.964-1.006
Fatty liver
17/13 (15)
6/8 (6)
0.395
0.574
0.159-2.066
γ-GT (U/L)
55 ± 48
59 ± 77
0.781
1.001
0.992-1.011
AST (IU/L)
24 ± 8
25 ± 10
0.769
1.009
0.948-1.075
ALT (IU/L)
24 ± 15
24 ± 12
0.906
0.998
0.958-1.039
hs-CRP (mg/dL)
0.107 ± 0.142
0.101 ± 0.116
0.890
0.706
0.005-98.830
MS
15/14 (16)
6/8 (6)
0.586
0.700
0.194-2.530
Table 3 Multivariate analysis of variables associated with Barrett’s epithelial dysplasia
Risk factor
P value
OR
95%CI
p53
0.004
13.107
2.275-75.504
H. pylori
0.066
0.187
0.031-1.116
Diastolic BP
0.021
0.874
0.780-0.980
Table 4 Analysis of variance for the three categories of Barrett’s epithelium: non-dysplasia, low-grade dysplasia, and high-grade dysplasia
No dysplasia (n = 45)
Low grade (n = 14)
High grade (n = 6)
P value
Sex (male/female)
Dec-33
13/1
6/0
0.177
Age (yr)
65.0 ± 9.8
64.3 ± 12.4
63.8 ± 9.4
0.941
Length of BE (SSBE/LSBE)
Feb-43
14/0
4/2
0.044
H. pylori infection rate
Sep-34
6/7
1/5
0.002
p53 positive rate
4/41
7/7
6/0
< 0.001
Body weight (kg)
61.0 ± 9.7
69.5 ± 9.8
65.5 ± 12.5
0.033
BMI (kg/m2)
23.1 ± 2.8
24.0 ± 3.1
23.3 ± 3.7
0.689
Waist circumference (cm)
86.9 ± 7.9
88.1 ± 9.6
89.3 ± 8.4
0.848
GERD
19/26
9/5
0/6
0.020
Hypertension (BP > 130/85)
29/14
6/7
3/3
0.155
Systolic BP (mmHg)
127 ± 16
120 ± 19
125 ± 6
0.473
Diastolic BP (mmHg)
76 ± 10
69 ± 9
71 ± 6
0.016
Diabetes
14/25
7/6
3/3
0.425
Fasting blood glucose (mg/dL)
118 ± 32
113 ± 19
108 ± 20
0.712
HbA1c (%)
5.6 ± 1.0
5.5 ± 0.7
5.5 ± 0.8
0.971
Dyslipidemia
24/19
5/8
3/3
0.612
TG (mg/dL)
144 ± 58
118 ± 71
183 ± 137
0.190
TC (mg/dL)
202 ± 30
195 ± 36
174 ± 25
0.124
HDL-C (mg/dL)
55 ± 13
55 ± 9
48 ± 7
0.407
LDL-C (mg/dL)
118 ± 26
112 ± 33
97 ± 17
0.201
Fatty liver
17/13
5/7
1/1
0.744
γ-GTP (U/L)
55 ± 48
40 ± 31
101 ± 126
0.097
AST (IU/L)
24 ± 8
26 ± 10
24 ± 10
0.837
ALT (IU/L)
24 ± 15
25 ± 13
21 ± 10
0.803
Hs-CRP (mg/dL)
0.107 ± 0.142
0.104 ± 0.126
0.084 ± 0.029
0.973
Metabolic syndrome
15/14
4/7
2/1
0.604
Table 5 Relationship between the level of p53 expression and grade of dysplasia
Normal (n = 45)
Low grade (n = 14)
High grade and Ca (n = 6)
p53 (-)
41
7
0
p53 (+)
4
4
4
p53 (++)
0
3
2
Citation: Fujita M, Nakamura Y, Kasashima S, Furukawa M, Misaka R, Nagahara H. Risk factors associated with Barrett’s epithelial dysplasia. World J Gastroenterol 2014; 20(15): 4353-4361