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World J Gastroenterol. Apr 21, 2014; 20(15): 4353-4361
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4353
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4353
Risk factors associated with Barrett’s epithelial dysplasia
Mikiko Fujita, Yuri Nakamura, Saeko Kasashima, Maiko Furukawa, Ryoichi Misaka, Hikaru Nagahara, Department of Gastroenterology, Aoyama Hospital, Tokyo Women’s Medical University, Tokyo 1070061, Japan
Author contributions: Fujita M, Misaka R and Nagahara H designed the study and wrote the manuscript; Fujita M, Nakamura Y, Kasashima S and and Furukawa M performed the endoscopic diagnosis and acquired the data; Misaka R and Nagahara H analyzed and interpreted the data; Nagahara H gave final approval to the version to be published.
Correspondence to: Hikaru Nagahara, Professor, Department of Gastroenterology, Aoyama Hospital, Tokyo Women’s Medical University, 2-7-13 Kitaaoyama, Minato-ku, Tokyo 1070061, Japan. nagahara.hikaru@twmu.ac.jp
Telephone: +81-3-54118111 Fax: +81-3-54118126
Received: September 5, 2013
Revised: October 27, 2013
Accepted: November 18, 2013
Published online: April 21, 2014
Revised: October 27, 2013
Accepted: November 18, 2013
Published online: April 21, 2014
Core Tip
Core tip: Barrett’s esophagus (BE) is known to be a precancerous state of adenocarcinoma will become common in Asian countries, therefore, it is important to establish a high-risk group or strategy for screening or follow-up of BE. We present here the results of univariate and multivariate analysis to identify variables associated with dysplasia of BE. p53 expression in immunohistochemistry was associated with dysplasia, and Helicobacter pylori infection and high diastolic blood pressure may act as protective factors against dysplastic change of BE. These three factors may be candidates to establish a high-risk group for esophageal adenocarcinoma.