Preclinical evaluation of herpes simplex virus armed with granulocyte-macrophage colony-stimulating factor in pancreatic carcinoma

Table 1 Inhibition of OrienX010 on the growth of PANC-2 pancreatic carcinoma xenografts in mice

Administration	Host (mice) reaction		Tumor reaction
	Animal number	Body weight, g (mean ± SD)	Tumor weight, g	Z	Tumor volume	J	RTV	T/C (%)
	beginning/end	beginning/end	(mean ± SD)		(mm3)
	10/10	16.5 ± 1.2/19.8 ± 1.9	2.10 ± 1.41		3555.8 ± 1849.8		15.4 ± 5.7
Tumor injection × 4	10/10	16.4 ± 0.9/18.2 ± 2.4	1.04 ± 0.45	50.50%	1668.3 ± 661.9	53.10%	7.0 ± 2.5b	45.5
Tumor injection × 4	10/10	16.0 ± 0.6/18.6 ± 1.3	1.12 ± 0.55	46.70%	1869.8 ± 846.6	47.40%	8.5 ± 4.4b	55.2
Tumor injection × 4	10/10	16.2 ± 0.8/18.5 ± 0.8	1.23 ± 0.39	41.40%	2200.3 ± 826.5	38.10%	10.1 ± 4.2a	65.6

^aP < 0.05,

^bP < 0.01 vs control group; Z: Inhibition rate of tumor weight; J: Inhibition rate of tumor volume; RTV: Relative tumor volume.