Analysis of CD117-negative gastrointestinal stromal tumors

Table 1 Clinical data of CD117-negative GISTs harboring KIT mutations.

Case Number	Age (yr) Sex Location	Tumor size1 Cell type MI2	S-100	SMA3 or desmin	Clinical behavior (follow-up months)
#23	52 Female Stomach	4.5 cm Spindle MI = 2	+	-	No evidence of disease after excision (24 mo)
#106	69 Female Stomach	5.5 cm Spindle MI = 30	-	-	No evidence of disease after excision (15 mo)
#112	44 Male Rectum	13 cm Spindle MI = 7	-	-	No evidence of disease after excision (12 mo)
#133	56 Male Rectum	6 cm Spindle MI = 13	-	-	Alive with local recurrence for 5 times (35 mo)
#142	45 Female Small intestine	15 cm Spindle MI = 367	-	-	Died of disease (48 mo); failed to Grivec treatment
#146	53 Female Small intestine	17 cm Mixed MI = 100	-	-	Alive with multiple metastasis (36 mo); remission after Glivec treatment
#151	50 Female Stomach	40 cm Spindle MI = 3	+	+	No evidence of disease after excision (17 mo)

¹Size represents the single greatest dimension.

²MI, mitotic index (mitoses per 50 high power fields).

³SMA, α-smooth muscle actin.