Potential effects of L-NAME on alcohol-induced oxidative stress

Table 1 Plasma transaminase activities, prooxidant and antioxidant status in groups.

	Control (Group 1)	ETOH (Group 2)	ETOH + L-NAME (Group 3)	P1	P2	P3
ALT (U/L)	24.25±4.07	62.00±6.73	37.00±4.73	<0.001	<0.001	<0.001
AST (U/L)	38.92±6.42	128.42±16.98	81.33±14.90	<0.001	<0.001	<0.001
MDA (mmol/L)	2.65± 0.30	4.66±0.64	3.43±0.35	<0.001	<0.001	<0.001
NO (mmol/L)	34.67±4.69	54.67±9.19	27.50±4.34	<0.001	<0.001	<0.001
SOD (U/mL)	20.00±1.86	15.25±0.97	19.00±1.54	<0.001	<0.001	NS
CAT (U/mL)	176.0±11.23	145.33±9.23	166.83±7.27	<0.001	<0.001	<0.05
GSH (mg/g Hb)	5.52±0.41	4.12±0.32	5.64±0.52	<0.001	<0.001	NS

¹Group 1 vs group 2; ²Group 2 vs group 3; ³Group 1 vs group 3. NS: Not-significant.

Table 2 Hepatic prooxidant and antioxidant status in groups.

	Control (Group 1)	ETOH (Group 2)	ETOH + L-NAME (Group 3)	P1	P2	P3
MDA (nmol/mg protein)	0.34±0.05	0.55±0.08	0.36±0.07	<0.001	<0.001	NS
NO (nmol /mg protein)	435.33±35.64	586.50±34.79	412.75±38.67	<0.001	<0.001	<0.001
SOD (U/mg protein)	8.13±0.79	5.38±0.75	6.93±0.81	<0.001	<0.001	<0.01
CAT (U/mg protein)	72.58±7.37	36.50±6.65	61.17±7.81	<0.001	<0.001	<0.01
GSH (nmol/mg protein)	4.49±0.51	3.55±0.36	4.18±0.26	<0.001	<0.001	NS

¹Group 1 vs group 2; ²Group 2 vs group 3; ³Group 1 vs group 3. NS: Not-significant.