Ginkgo biloba extract reverses CCl4&ndash;induced liver fibrosis in rats

doi:10.3748/wjg.v10.i7.1037

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Apr 1, 2004 (publication date) through Apr 26, 2024

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Times Cited (31)

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Apr 1, 2004; 10(7): 1037-1042
Published online Apr 1, 2004. doi: 10.3748/wjg.v10.i7.1037

Table 1 Rat liver weight (LW), body weight (BW) and spleen weight (SW)

	BW (g)	LW (g)	LW/BW (%)	SW (g)	SW/BW (%)
C	297.0 ± 39.6^d	14.6 ± 3.0	4.9 ± 0.7^c	1.5 ± 0.2	0.5 ± 0.06^d
E	343.3 ± 25.7^b	9.6 ± 4.2^b^c	2.8 ± 0.4^b^c	1.0 ± 0.1^b^d	0.3 ± 0.03^b^d
Z	351.1 ± 21.6^b	13.2 ± 3.3	3.7 ± 0.4^a	1.4 ± 0.1	0.4 ± 0.04^b
N	358.3 ± 72.2^a	11.4 ± 0.5^a^c	3.2 ± 0.1^a^d	0.7 ± 0.1^b^d	0.2 ± 0.02^b^d

^aP < 0.05,

^bP < 0.01 vs C group;

^cP < 0.05,

^dP < 0.01 vs Z group.

Table 2 Rat liver histopathology

Liver fibrosis						Collagen(%)	Reticulum(%)	αSMA(+)(%)
	0	I	II	III	IV	Collagen(%)	Reticulum(%)	αSMA(+)(%)
C	0	0	0	3	3	11.4 ± 1.2^d	12.4 ± 0.9^d	4.8 ± 2.1^c
E	5	1	0	0	0	4.6 ± 0.9^b^d	4.0 ± 1.1^b^d	2.6 ± 0.4^b^c
Z	0	1	3	2	0	9.1 ± 1.0^b	10.4 ± 0.9^b	3.5 ± 1.6^a
N	6	0	0	0	0	0.1 ± 0.1^b^d	1.0 ± 0.3^b^d	1.0 ± 0.1^b^d

^aP < 0.05,

^bP < 0.01 vs group C;

^cP < 0.05,

^dP < 0.01 vs group Z.

Table 3 Liver function parameters

	ALT (U/L)	AST (U/L)	Albumin (g/L)	TBIL (mg/L)
C	188.8 ± 52.8	267.8 ± 45.4^c	22.2 ± 1.7^d	9.3 ± 1.1^d
E	80.8 ± 15.2^b^d	108.1 ± 23.4^b^d	35.8 ± 3.2^b^d	5.6 ± 0.9^b^d
Z	143.1 ± 35.0	211.6 ± 53.1^a	28.7 ± 1.9^b	7.0 ± 0.8^b
N	43.4 ± 7.7^b^d	101.3 ± 22.2^b^d	36.3 ± 1.3^b^d	5.3 ± 0.8^b^d

^aP < 0.05,

^bP < 0.01 vs group C;

^cP < 0.05,

^dP < 0.01 vs group Z.

Citation: Luo YJ, Yu JP, Shi ZH, Wang L. Ginkgo biloba extract reverses CCl₄–induced liver fibrosis in rats. World J Gastroenterol 2004; 10(7): 1037-1042
URL: https://www.wjgnet.com/1007-9327/full/v10/i7/1037.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i7.1037