Expression of nuclear factor-kappa B and target genes in gastric precancerous lesions and adenocarcinoma: Association with Helicobactor pylori cagA (+) infection

Table 1 Expression of NF-κB/p65 and its target genes in IM, DYS, GC infected with H pylori

	n	NF-κB/p65 positive(n)	%	C-myc positive (n)	%	CyclinD1 positive (n)	%	Bcl-xl positive (n)	%
IM I-II	50	32	64.00	35	70.00	34	68.00	33	66.00
IM III	72	51	70.83	55	76.39	56	77.78	51	70.83
DYS I	51	33	64.71	36	70.59	35	68.63	34	66.67
DYS II-III	53	34	64.15	39	73.58	34	64.15	28	52.83
GC	63	45	71.43	33	52.38	37	58.73	44	69.84

Table 2 Expression of NF-κB/p65 and target genes in IM, DYS, GC infected with and without cagA H pylori

	CagA (n)	NF-κB/p65 positive(n)	χ2	Exact	C-myc posotive(n)	χ2	Exact	CyclinD1 positive(n)	χ2	Exact	Bc1-x1 positive(n)	χ2	Exact
IM I-II	+33	28	18.311	0.000	22	0.514	0.533	21	0.849	0.524	21	0.242	0.757
	-17	4			13			13			12
IM III	+52	48	41.785	0.000	47	20.331	0.000	49	29.319	0.000	46	28.158	0.000
	-20	3	41.785		8			7			5
Dys I	+31	27		0.000	22	0.005	1.000	22	0.201	0.760	21	0.041	1.000
	-20	3	26.089		14			13			13
Dys II-III	+32	28		0.000	29	12.065	0.001	26	10.268	0.001	25	20.736	0.000
	-21	6	19.154		10			8			3
GC	+40	35		0.000	21	0.128	0.721	25	0.642	0.432	30	1.384	0.239
	-23	10	13.867		11			12			14

Table 3 Relationship between expression of NF-κB/p65, its target genes and clinicopathology of GC infected with cagA H pylori

Clinicopathology	n	NF-κB/p65 positive (n)	χ2	P	C-myc positive (n)	χ2	P	CyclinD1 positive (n)	χ2	P	Bcl-xl positive (n)	χ2	P
Early stage	13	9	5.877	0.031	3	6.687	0.017	7	0.615	0.498	5
Advanced stage	27	26			18			18			10	0.008	1.000
Intestinal type	28	27	6.803	0.022	18	5.199	0.038	22	10.286	0.003	24
Diffuse type	12	8			3			3			6	5.714	0.041
Metastasis of LN	30	26	0.076	1.000	19	5.647	0.028	16	4.302	0.060	22
No metastasis of LN	10	9			2			9			8	0.178	1.000