Relation between HBsAg/IgM circulating immune complex and hepatic injury

doi:10.3748/wjg.v4.iSuppl2.130

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 4, Issue Suppl2

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (712)

All Articles published online

The chart showing PDF series, HTML series.

Item

Count

PDF

HTML

645

Sum=712

Oct 15, 1998 (publication date) through Apr 23, 2024

Times Cited of This Article

Times Cited (1)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Abstracts Open Access

World J Gastroenterol. Oct 15, 1998; 4(Suppl2): 130-130
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.130

Relation between HBsAg/IgM circulating immune complex and hepatic injury

Zuo-Mei Huang, Shui-Bin Yuan, Dong-Lian Yang

Zuo-Mei Huang, Department of Bsic Science Tumor institute of Jiangxi Province 330029, China

Shui-Bin Yuan, Dong-Lian Yang, Department of Laboratory Medicine, Cancer Hospital of Jiangxi Province 330029, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Zuo-Mei Huang, Department of Bsic Science Tumor institute of Jiangxi Province 330029, China

Received: July 12, 1998
Revised: August 13, 1998
Accepted: September 9, 1998
Published online: October 15, 1998

Abstract

AIM: To observe the relation between HBsAg/IgM circulating immune complex (CIC) and hepatic injury.

METHODS: Serum HBsAg/IgM CIC were measured by capture-ELISA, Alanine aminotransferase (ALT) were detected in 31 symptomless subjects with HBs Ag-positive, 60 patients with acute Hepatitis B, 78 with chronic active Hepatit is B, 18 with severe Hepatitis B, 49 with hepatic cirrhosis caused by Hepatitis B respectively.

RESULTS: The results showed that the positive rates of HBsAg/IgM CIC in various Hepatitis B were arranged from high to low in order of hepatic cirrhosis > severe Hepatitis > chronic Hepatitis > acute Hepatitis > symptomless HBsAg positive subjects. Among 236 cases with various Hepatitis B, 132 cases had abnormal level ALT and the HBsAg/IgM CIC positive rate was 50.0% (66/132), and 104 case with normal ALT, the HBsAg/IgM CIC positive rate was 32. 7% (24/104). There was significant differences between the two groups (P < 0.01). Based on clinical type, the positive rates of HBsAg/IgM CIC were 3.2% (1/31) in 31 symptomless HBsAg-positive persons; 33.3% (4/12) in patients with acute hepatitis and normal ALT, 37.5% (18/48) in patients with acute hepatitis and abnormal ALT (P > 0.05); 43.8% (14/32) in patients with chronic-hepatitis and normal ALT, 50.0% (23/46) in chronic-hepatitis and abnormal ALT(P > 0.05), 16.7% (1/6) in patients with severe-hepatitis and norm al ALT, 75.0% (9/12) in patients with severe hepatitis with abnormal ALT (P < 0.05); 60.9% (14/23) in patients with hepatic cirrhosis and normal ALT, 61.5% (16/26) in patients with hepatic cirrhosis and abnormal ALT (P > 0.05) respectively.

CONCLUSION: The positive rates of HBsAg/IgM CIC are closely related to hepatic injury.

Key Words: Hepatitis B, IgM, Antigen-antibody complex, Hepatitis B, Hepatitis B surface antigens

Citation: Huang ZM, Yuan SB, Yang DL. Relation between HBsAg/IgM circulating immune complex and hepatic injury. World J Gastroenterol 1998; 4(Suppl2): 130-130
URL: https://www.wjgnet.com/1007-9327/full/v4/iSuppl2/130.htm
DOI: https://dx.doi.org/10.3748/wjg.v4.iSuppl2.130

Footnotes

E- Editor: Li RF