Exploration on treatment of chronic superficial gastritis and gastric precancerosis with integrated Chinese and Western medicine

Abstract

AIM: Gentamicin and Bi agent (trilogy) were used to eradicate Hp, KANGWEIHUAATANG of Chinese traditional Medication was used to enhance physio logical function of gastric mucosa, to improve gastric mucosal circulation, to reinforce blood flow and to make atrophied intestinal metaplastic cell reversion. They stop developing from gastric precancerosis to gastric carcinoma.

METHODS: Fifty gastritis patients with Hp(+), intestinal metaplasia and partial atrophy were confirmed diagnosis by gastroscope and pathological baoteriology examination. They were treated with amoxioillin 0.75 g three times every day; gentamicin 80000 unit three times every day; Lizhuchangle diluent 110 mg four times every day. Continuous 3 wk is a course of treatment. Kang wei hua tang of Chinese traditional medication were made by the author himself (radix codonopsis, radix astragali, herba-taraxaci, rhizoma pinelliae, aspongopus, rhizoma corydalis, fructus amomi, radix cynanchi paniculati, lasiophaera seu calvatia, herba hedyotis diffusae). A dosage was divided in to two times to be decocted and taken orally every day, 250 cc-300 cc every time. Continuous 4 wk is a course of treatment. Reexamination was undergone after a mouth of the end of treatment.

RESULTS: Fifty cases with Hp(+) concomitant intestimal metaplasia and sixteen cases with partial atrophy gastritis have been reexaminated after all courses of treatment. There were forty-three cases with Hp reversing negation and twenty-six cases with disappearance of treatment intestinal metaplasia, among which there were sixteen cases with intestinal metaplasia linking atrophy, atrophy disappear in fifteen cases.

CONCLUSION: Trilogy therapy was employed to eradicate Hp, Chinese traditional medicine kang wei hua tang blocked the development from gastric precancer to gastric carcinoma, and promoted the reversion of gastric precancer. In fifty cases treated, elimination rate of Hp was 86%, elimination rate of intestinal metaplasia was 52%, among which there were sixteen cases of intestinal metaplasia linking atrophy, fifteen cases of them showed disappearance of atrophy, cure rate 94%. It demonstrated certain effect that trilogy therapy combined with Chinese traditional medicine kang wei hua tang treated gastritis and pre-cancerous lesion, and demands further investigation.

Key Words: Gastritis/therapy; Stomach neoplasms/therapy; Drugs, chinese herbal; CTM-WM therapy