Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.130
Revised: August 13, 1998
Accepted: September 9, 1998
Published online: October 15, 1998
AIM: To observe the relation between HBsAg/IgM circulating immune complex (CIC) and hepatic injury.
METHODS: Serum HBsAg/IgM CIC were measured by capture-ELISA, Alanine aminotransferase (ALT) were detected in 31 symptomless subjects with HBs Ag-positive, 60 patients with acute Hepatitis B, 78 with chronic active Hepatit is B, 18 with severe Hepatitis B, 49 with hepatic cirrhosis caused by Hepatitis B respectively.
RESULTS: The results showed that the positive rates of HBsAg/IgM CIC in various Hepatitis B were arranged from high to low in order of hepatic cirrhosis > severe Hepatitis > chronic Hepatitis > acute Hepatitis > symptomless HBsAg positive subjects. Among 236 cases with various Hepatitis B, 132 cases had abnormal level ALT and the HBsAg/IgM CIC positive rate was 50.0% (66/132), and 104 case with normal ALT, the HBsAg/IgM CIC positive rate was 32. 7% (24/104). There was significant differences between the two groups (P < 0.01). Based on clinical type, the positive rates of HBsAg/IgM CIC were 3.2% (1/31) in 31 symptomless HBsAg-positive persons; 33.3% (4/12) in patients with acute hepatitis and normal ALT, 37.5% (18/48) in patients with acute hepatitis and abnormal ALT (P > 0.05); 43.8% (14/32) in patients with chronic-hepatitis and normal ALT, 50.0% (23/46) in chronic-hepatitis and abnormal ALT(P > 0.05), 16.7% (1/6) in patients with severe-hepatitis and norm al ALT, 75.0% (9/12) in patients with severe hepatitis with abnormal ALT (P < 0.05); 60.9% (14/23) in patients with hepatic cirrhosis and normal ALT, 61.5% (16/26) in patients with hepatic cirrhosis and abnormal ALT (P > 0.05) respectively.
CONCLUSION: The positive rates of HBsAg/IgM CIC are closely related to hepatic injury.