Efficiency of olaparib in colorectal cancer patients with an alteration of the homologous repair protein
Francois Ghiringhelli, Department of Medical Oncology, Center GF Leclerc, 21000 Dijon, France
Francois Ghiringhelli, Corentin Richard, Sandy Chevrier, Frédérique Végran, Romain Boidot, Platform of Transfer in Oncology, Center GF Leclerc, 21000 Dijon, France
Francois Ghiringhelli, Romain Boidot, Frederique Vegran, INSERM UMR866, 21000 Dijon, France
Francois Ghiringhelli, Corentin Richard, University of Bourgogne Franche Comte, 21000 Dijon, France
Author contributions: Ghiringhelli F and Boidot R designed the report; Richard C, Chevrier S and Végran F performed the genetic analyses; Ghiringhelli F collected the patient’s clinical data; Ghiringhelli F and Boidot R analyzed the data and wrote the paper.
Institutional review board statement: This study was approved by the local institutional review board.
Informed consent statement: Patients gave their written consent to authorize genetic analyses.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Francois Ghiringhelli, MD, PhD, Professor, Department of Medical Oncology, Center GF Leclerc, 21000 Dijon, France. email@example.com
Telephone: +33-380393371 Fax: +33-380393434
Received: July 7, 2016
Peer-review started: July 11, 2016
First decision: August 22, 2016
Revised: August 26, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: December 28, 2016