Efficiency of olaparib in colorectal cancer patients with an alteration of the homologous repair protein

doi:10.3748/wjg.v22.i48.10680

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2016; 22(48): 10680-10686
Published online Dec 28, 2016. doi: 10.3748/wjg.v22.i48.10680

Table 1 Alterations observed for Case 1 in the short list of clinically relevant genes

Gene	Nucleotide variation	Protein variation	Origin	Impact
AKT1	c.235C>A	Gln79Lys	Somatic	Activating
CCNE1	c.1022C>T	Thr341Met	Somatic	Unknown
CHEK2	c.478A>G	Arg117Gly	Constitutive	Likely pathogenic
CUL2	c.70C>T	Pro24Ser	Somatic	Unknown
ERCC6	c.4179G>A	Met1393Ile	Somatic	Unknown
PMS2	c.1531A>G	Thr511Ala	Constitutive	Benign
SMAD4	c.1091T>A	Leu364X	Somatic	Loss of function
SUFU	c.1211T>C	Met404Thr	Constitutive	Unknown

Citation: Ghiringhelli F, Richard C, Chevrier S, Végran F, Boidot R. Efficiency of olaparib in colorectal cancer patients with an alteration of the homologous repair protein. World J Gastroenterol 2016; 22(48): 10680-10686
URL: https://www.wjgnet.com/1007-9327/full/v22/i48/10680.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i48.10680