Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C
Rosario López-Rodríguez, Leticia González-Moreno, Yolanda Real-Martínez, Luisa García-Buey, Ricardo Moreno-Otero, Paloma Sanz-Cameno, Ángel Hernández-Bartolomé, Liver Unit, Gastroenterology Service, Instituto Investigación Sanitaria Princesa, IIS-IP, 28006 Madrid, Spain
María Jesús Borque, Molecular Biology Unit, Instituto Investigación Sanitaria Princesa, IIS-IP, 28006 Madrid, Spain
Luisa García-Buey, Ricardo Moreno-Otero, Paloma Sanz-Cameno, CIBERehd, 28006 Madrid, Spain
Author contributions: Hernández-Bartolomé A contributed to acquisition, analysis and interpretation of data, final approval given; López-Rodríguez R contributed to acquisition, analysis and interpretation of data, critical revision of the manuscript, final approval given; Borque MJ contributed to acquisition of data; González-Moreno L, Real-Martínez Y, García-Buey L and Moreno-Otero R contributed to clinical management of patients, critical revision of the manuscript, final approval given; Sanz-Cameno P contributed to conception and design of the study, analysis and interpretation of data, drafting of the manuscript and final approval given.
Supported by the Ministerio de Ciencia e Innovación (SAF: 2010/21805, partially); CIBERehd (Instituto de Salud Carlos III, Madrid); Fundación Mutua Madrileña (to Moreno-Otero R); and a grant from Asociación Española Contra el Cáncer (AIO 2010, AECC, to Sanz-Cameno P).
Institutional review board statement: This study was reviewed and approved by the clinical research ethics committee of Hospital Universitario de la Princesa.
Informed consent statement: Written informed consent was obtained from all subjects at the time of enrollment or blood sampling.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Paloma Sanz-Cameno, PhD, Liver Unit, Gastroenterology Service, Instituto Investigación Sanitaria Princesa, IIS-IP, 28006 Madrid, Spain. firstname.lastname@example.org
Telephone: +34-91-5202334 Fax: +34-91-4022299
Received: May 28, 2016
Peer-review started: May 30, 2016
First decision: August 8, 2016
Revised: September 9, 2016
Accepted: October 10, 2016
Article in press: October 10, 2016
Published online: November 28, 2016