Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C

Table 1 Baseline characteristics of chronic hepatitis C patients

Patients	Cirrhotic (n = 31)	Non-cirrhotic (n = 148)	P value
Sex (M/F)	23/8	92/56	0.20
Age (yr)	48 (24-63)	44 (22-67)	0.23
Viral load (× 105 IU/mL)	5.0 (3.5-11.0)	7.1 (1.8-13.0)	0.68
HCV genotype, n (%)			-
1	27 (87.1)	117 (79.1)
Non-1	4 (12.9)	31 (20.9)
Stage of liver fibrosis, n (%)			-
F1	-	42 (28.4)
F2	-	66 (44.6)
F3	-	40 (27.0)
F4	31 (100.0)	-
AST (UI/L)	99.0 (60.0-123.0)	48.0 (33.0-65.0)	< 0.001
ALT (UI/L)	116.0 (87.0-161.0)	74.0 (55.3-111.5)	< 0.001
ALP (UI/L)	116.0 (75.0-220.0)	126.5 (77.5-164.8)	0.39
GGT (UI/L)	91.0 (68.0-172.0)	36.0 (23.0-65.8)	< 0.001
INR	1.1 (1.1-1.2)	1.0 (0.9-1.1)	< 0.001
Bilirubin (mg/dL)	0.9 (0.7-1.1)	0.6 (0.5-0.8)	< 0.001
Platelet count (× 109/L)	141.0 (120.0-167.0)	204.0 (167.0-241.0)	< 0.001
Cholesterol total (mg/dL)	163.0 (141.0-180.0)	171.0 (154.3-191.5)	0.06
Albumin (g/dL)	4.2 (4.0-4.4)	4.3 (4.2-4.6)	0.03

Data are shown as number of patients (percentage) or median value (25^th-75^th percentile), except for age (median and range). HCV: Hepatitis C virus; AST: Aspartate transaminase; ALT: Alanine transaminase.