TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury

Table 4 Lung injury score in all groups (mean ± SD)

Group (n = 6)	Alveolar congestion	Hemorrhage	Neutrophil infiltration	Alveolar wall thickness	Total score
Sham	1.18 ± 0.21	0.63 ± 0.27	0.23 ± 0.08	0.17 ± 0.08	2.22 ± 0.64
Control	3.82 ± 0.18	2.72 ± 0.18	1.85 ± 0.15	2.37 ± 0.23	10.75 ± 0.73a
Anti-HMGB1	2.05 ± 0.12	1.02 ± 0.26	0.47 ± 0.10	0.55 ± 0.14	4.08 ± 0.60ab
Anti-MyD88	3.07 ± 0.16	2.13 ± 0.26	0.87 ± 0.18	1.08 ± 0.23	7.15 ± 0.77abc
Anti-TRIF	2.93 ± 0.16	1.92 ± 0.18	0.77 ± 0.14	1.02 ± 0.16	6.63 ± 0.62abc

^aP < 0.05 vs sham group;

^bP < 0.05 vs control group;

^cP < 0.05 vs anti-HMGB1 group. HMGBI: High-mobility group protein 1; MyD88: Myeloid differentiation gene 88; TRIF: Translocating-chain-associating membrane protein.