Basic Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Mar 28, 2015; 21(12): 3527-3536
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3527
Figure 5
Figure 5 Interferon-α or entecavir treatment decreases hepatitis B virus DNA in hydrodynamically injected C3H/HeN mice. HI mouse model of HBV was created in 5-6-wk-old male C3H/HeN mice. IFN-α, entecavir or PBS treatment was performed on those mice 5 wk post HI. The black dot group (n = 5) was intragastrically administrated with 0.1 mg/kg entecavir once a day for 14 d; the open square group (n = 5) was intraperitoneally injected with 1 mg/kg IFN-α twice a week for 2 wk; the open dot group was treated with PBS as a control. Serum specimens were collected and assayed for HBV DNA on days 0, 7 and 14 after treatment. HBV: Hepatitis B virus; HI: Hydrodynamic injection; IFN: Interferon.