The role of endotoxin, TNF-α, and IL-6 in inducing the state of growth hormone insensitivity

Figure 1 (A, B) Liver IGF-I mRNA expression response to endotoxin injection at different time points. (C) Liver IGF-I mRNA expression after single GH injection and endotoxin injection along with or without GH injection. ^bP < 0.05 compared with NS + NS group, ^cP < 0.01 vs NS + NS group, ^dP > 0.05 compared with LPS + NS group. NS as saline injection.

Figure 2 (A, B) Liver GHR mRNA expression responsed to endotoxin injection at different time points. (C) Liver GHR mRNA expression after single GH injection and endotoxin injection along with or without GH injection. ^aP > 0.05 compared with NS + NS group, ^cP < 0.01 vs NS + NS group, ^dP > 0.05 compared with LPS+NS group. NS as saline injection.

Figure 3 (A, B) Liver SOCS-3 mRNA expression response to endotoxin injection at different time points. (C) Liver SOCS-3 mRNA expression after endotoxin injection along with or without GH injection. ^aP > 0.05 compared with NS + NS group, ^cP < 0.01 vs NS + NS group, ^dP > 0.05 compared with LPS + NS (7.5) group. NS as saline injection.

Figure 4 LiverGHR (A) and SOCS-3 (B) mRNA expression response to TNF-α and IL-6 iv injection at different time points.