Effects of AT1 receptor antagonist, losartan, on rat hepatic fibrosis induced by CCl4

Figure 1 Collagen expression in liver section of model rat (van Gieson staining, × 200) (A), and of losartan treated group (van Giesion staining, × 200). Significantly less fibrosis can be noted compared to that in the model group (B).

Figure 2 AT1 receptor expression in liver section of model rat (DAB staining, × 200). AT1 receptor is seen mainly scattered in fibrotic areas and vascular wal l (A), and of los artan treated group (DAB staining, × 200). Note significantly less AT1 expression than that seen in the model group (B).

Figure 3 TGF-β expression in liver section of model rat ( DAB staining, × 200). TGF-β expression is seen scattered in the fibrotic areas and vascular wall (A), and of losart an treated group (DAB staining, × 200). Note significantly less TGF-β expression than that seen in the model group (B).