Fatty liver in H63D homozygotes with hyperferritinemia

Figure 1 Case 1 liver histology. A: Hematoxylin and eosin staining shows grade 2 hepatic steatosis; B: Perls’ staining shows grade 1 hepatocyte siderosis with predominant periportal distribution; C: Higher power of Perls’ staining shows clustered Kupffer cell siderosis (right lower field) and also irregular large granular deposits in sinusoidal cells.

Figure 2 Case 2 liver histology. A: Hematoxylin and eosin staining shows grade 2 hepatic steatosis; B: Perls’ staining shows grade 2 hepatocyte siderosis with predominant periportal distribution; C: Higher power shows focal Kupffer cell siderosis and more granular irregular sinusoidal siderosis.