Effect of O-4-ethoxyl-butyl-berbamine in combination with pegylated liposomal doxorubicin on advanced hepatoma in mice

Figure 1 Antitumor activity of Dox or PLD alone or in combi-nation with EBB in mice with hepatoma.

Figure 2 Dox concentrations in tumor tissues from mice after i. v. injection of Dox (10 mg/kg) or PLD (equal to 10 mg/kg Dox) in combination with EBB (5 mg/kg).

Figure 3 Histopathological changes in livers of tumor-bearing mice treated with saline (A), Dox (B), Dox + EBB (C), PLD (D) or PLD + EBB (E). (Original magnification, × 200).

Figure 4 IC₅₀ value of Dox or PLD alone or in combination with EBB.