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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2025; 31(18): 104206
Published online May 14, 2025. doi: 10.3748/wjg.v31.i18.104206
Published online May 14, 2025. doi: 10.3748/wjg.v31.i18.104206
Role of serological biomarkers in evaluating and predicting endoscopic activity in inflammatory bowel disease
Xue Liu, Lin-Xiao Pan, Jia-Xian Pei, Tian Pu, Hong-Tao Wen, Ye Zhao, Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Liu X, Pan LX, and Pei JX participated in the conception and design of the study and were involved in the acquisition, analysis and interpretation of data; Liu X wrote the manuscript; Pu T, Wen HT, and Zhao Y accessed and verified the study data. All authors critically reviewed and provided final approval of the manuscript; and all authors were responsible for the decision to submit the manuscript for publication.
Supported by Henan Natural Science Foundation, No. 232300421181.
Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital of Zhengzhou University Institutional Review Board (Approval No. 2024-KY-1476-002).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at E-mail address. Participants gave informed consent for data sharing.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ye Zhao, MD, Chief Physician, Professor, Department of Gastro
Received: December 23, 2024
Revised: March 29, 2025
Accepted: April 23, 2025
Published online: May 14, 2025
Processing time: 143 Days and 21.9 Hours
Revised: March 29, 2025
Accepted: April 23, 2025
Published online: May 14, 2025
Processing time: 143 Days and 21.9 Hours
Core Tip
Core Tip: This is a retrospective single-center observational study to examine the correlation of serum biomarkers with endoscopic activity of ulcerative colitis (UC) and Crohn’s disease (CD), evaluate their diagnostic significance, and develop nomogram models to forecast endoscopic activity. Many markers such as white blood cell, hemoglobin, hematocrit, platelet (PLT), neutrophil, C-reactive protein (CRP), erythrocyte sedimentation rate, albumin (ALB), globulin, ALB/globulin, CRP/ALB, CRP/lymphocyte, PLT/lymphocyte, PLT/ALB, and neutrophil/lymphocyte are associated with endoscopic activity in patients with UC and CD. We can predict endoscopic severity of UC and CD by using the nomogram models.