Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2020; 26(9): 933-946
Published online Mar 7, 2020. doi: 10.3748/wjg.v26.i9.933
Exosomal miR-182 regulates the effect of RECK on gallbladder cancer
Hong Zheng, Jin-Jing Wang, Li-Jin Zhao, Xiao-Rong Yang, Yong-Lin Yu
Hong Zheng, Jin-Jing Wang, Xiao-Rong Yang, Yong-Lin Yu, Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
Li-Jin Zhao, Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
Author contributions: Zheng H performed the majority of the experiments and analyzed the data; Wang JJ performed the molecular investigations; Zhao LJ designed and coordinated the research; Yang XR and Yu YL wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Affiliated Hospital of Zunyi Medical University.
Informed consent statement: All patients in our study provided informed consent.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hong Zheng, MD, Chief Physician, Department of Pathology, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563003, Guizhou Province, China.
Received: December 5, 2019
Peer-review started: December 5, 2019
First decision: December 30, 2019
Revised: January 8, 2020
Accepted: January 19, 2020
Article in press: January 19, 2020
Published online: March 7, 2020
Processing time: 92 Days and 0.4 Hours
Core Tip

Core tip: Gallbladder cancer (GC) is the most common biliary malignancy that mostly affects the elderly. At present, however, the specific role of exosomal miR-182 and RECK in GC remains unknown. The results of this study indicated that exosomal miR-182 could markedly promote the migration and invasion of GC cells by inhibiting RECK. Therefore, miR-182 could serve as a therapeutic target for GC.