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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2019; 25(46): 6752-6766
Published online Dec 14, 2019. doi: 10.3748/wjg.v25.i46.6752
Published online Dec 14, 2019. doi: 10.3748/wjg.v25.i46.6752
Mesenterico-portal vein invasion should be an important factor in TNM staging for pancreatic ductal adenocarcinoma: Proposed modification of the 8th edition of the American Joint Committee on Cancer staging system
Hong-Yu Chen, Xing Wang, Hao Zhang, Xu-Bao Liu, Chun-Lu Tan, Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Tan CL, Liu XB, and Chen HY designed the study; Chen HY, Wang X, and Zhang H acquired the data; Wang X and Chen HY analyzed and interpreted the data; Chen HY wrote the paper; Tan CL and Liu XB critically revised the manuscript for important intellectual content.
Supported by the 1.3.5 Project for Disciplines of Excellence , West China Hospital, Sichuan University, No. ZY2017302 1-3-5 ; and the Key Research and Development Projects of Sichuan Province , No. 2017SZ0132 and No. 2019YFS0042 .
Institutional review board statement: This study was reviewed and approved by the West China Hospital Review Board.
Informed consent statement: Study participants of the West China Hospital database provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The guidelines of the STROBE statement have been adopted.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chun-Lu Tan, MD, PhD, Associate Professor, Doctor, Surgeon, Department of Pancreatic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. chunlutan@163.com
Telephone: +86-28-85422474 Fax: +86-28-85422474
Received: October 15, 2019
Peer-review started: October 15, 2019
First decision: November 4, 2019
Revised: November 12, 2019
Accepted: November 29, 2019
Article in press: November 29, 2019
Published online: December 14, 2019
Peer-review started: October 15, 2019
First decision: November 4, 2019
Revised: November 12, 2019
Accepted: November 29, 2019
Article in press: November 29, 2019
Published online: December 14, 2019
Core Tip
Core Tip: The 8th edition of the American Joint Committee on Cancer staging system for pancreatic ductal adenocarcinoma restages tumors with mesenterico-portal vein (MPV) invasion into T1-3 diseases according to tumor size. However, the survival analysis indicated that these patients have similar prognoses. The modified staging system, which includes the factor of MPV invasion, provides improvements in predicting prognosis.