Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2019; 25(38): 5789-5799
Published online Oct 14, 2019. doi: 10.3748/wjg.v25.i38.5789
lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting miR-490-3p/ histone deacetylase 2 axis
Wei Dai, Jia-Liang Dai, Mao-Hua Tang, Mu-Shi Ye, Shuo Fang
Wei Dai, Jia-Liang Dai, Department of Hepatobiliary Surgery, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong Province, China
Mao-Hua Tang, Department of Infectious Disease, the Second Affiliated Hospital of Guangdong Medical University, Zhanjiang 524003, Guangdong Province, China
Mu-Shi Ye, Department of Surgery, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong Province, China
Shuo Fang, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China
Shuo Fang, Li KaShing Faculty of Medicine, the University of Hong Kong, Hong Kong, China
Author contributions: Dai W and Dai JL performed the majority of experiments and analyzed the data; Ye MS performed the molecular investigations; Tang MH designed and coordinated the research; Fang S wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Affiliated Hospital of Guangdong Medical University Ethics Committee.
Informed consent statement: All patients in our study provided informed consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shuo Fang, PhD, Attending Doctor, The Seventh Affiliated Hospital, Sun Yat-sen University, No. 628, Zhenyuan Road, Xinhu Street, Guangming New District, Shenzhen 518107, Guangdong Province, China. shuofangzhongshan@163.com
Telephone: +86-852-65923702 Fax: +86-852-65923702
Received: July 29, 2019
Peer-review started: July 29, 2019
First decision: August 17, 2019
Revised: August 30, 2019
Accepted: September 13, 2019
Article in press: September 13, 2019
Published online: October 14, 2019
Core Tip

Core tip: Long noncoding RNA (lncRNA)-SNHG15 is up-regulated in hepatocellular carcinoma (HCC) tissue and cell lines. HCC patients with up-regulated lncRNA-SNHG15 level were more likely to have larger tumor sizes and advanced clinical stage. lncRNA-SNHG15 promotes cell proliferation, migration and invasion in HCC cell lines. The miR-490-3p/histone deacetylase 2 axis was determined to be the target regulated by lncRNA-SNHG15 in HCC, and the regulatory mechanism of lncRNA-SNHG15 has been preliminarily illuminated.