Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5069
Peer-review started: June 26, 2019
First decision: July 20, 2019
Revised: July 25, 2019
Accepted: August 7, 2019
Article in press: August 7, 2019
Published online: September 14, 2019
Core tip: The liver is a vital organ for metabolic regulation and plays a major role in the nutrient utilization of the whole body. Although scientists have paid much attention to hepatic senescence, the precise mechanisms in, and the contribution of cellular senescence to liver diseases have yet to be clearly defined. In this review, we have summarized the mechanism of senescence in general and in the liver. We have also discussed whether hepatocellular senescence is beneficial or harmful to the liver in the light of published findings.