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World J Gastroenterol. Sep 14, 2019; 25(34): 5069-5081
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5069
Hepatic senescence, the good and the bad
Nazmul Huda, Gang Liu, Honghai Hong, Shengmin Yan, Bilon Khambu, Xiao-Ming Yin
Nazmul Huda, Gang Liu, Honghai Hong, Shengmin Yan, Bilon Khambu, Xiao-Ming Yin, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Author contributions: Huda N designed, prepared and edited the manuscript. Liu G, Hong H, Yan S and Khambu B contributed intellectually to this manuscript. Yin XM conceived, edited and finalized the manuscript.
Conflict-of-interest statement: The authors have declared that no conflict of interest exists.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Ming Yin, FAASLD, MD, PhD, Full Professor, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 975 W Walnut St, Indianapolis, IN 46202, United States. xmyin@iupui.edu
Telephone: +1-317-4916096 Fax: +1-317-4916639
Received: June 26, 2019
Peer-review started: June 26, 2019
First decision: July 20, 2019
Revised: July 25, 2019
Accepted: August 7, 2019
Article in press: August 7, 2019
Published online: September 14, 2019
Core Tip

Core tip: The liver is a vital organ for metabolic regulation and plays a major role in the nutrient utilization of the whole body. Although scientists have paid much attention to hepatic senescence, the precise mechanisms in, and the contribution of cellular senescence to liver diseases have yet to be clearly defined. In this review, we have summarized the mechanism of senescence in general and in the liver. We have also discussed whether hepatocellular senescence is beneficial or harmful to the liver in the light of published findings.