Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection
Bui Tien Sy, Nghiem Xuan Hoan, Hoang Van Tong, Christian G Meyer, Nguyen Linh Toan, Le Huu Song, Thirumalaisamy P Velavan, Vietnamese-German Center of Excellence in Medical Research, Hanoi, Vietnam
Bui Tien Sy, Nghiem Xuan Hoan, Le Huu Song, Institute of Clinical Infectious Diseases, 108 Military Central Hospital, Hanoi, Vietnam
Nghiem Xuan Hoan, Christian G Meyer, Claus-Thomas Bock, Thirumalaisamy P Velavan, Institute of Tropical Medicine, University of Tübingen, Tübingen 72074, Germany
Hoang Van Tong, Nguyen Linh Toan, Thirumalaisamy P Velavan, Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam
Claus-Thomas Bock, Department of Infectious Diseases, Robert Koch Institute, Berlin 13302, Germany
Author contributions: Velavan TP and Sy BT designed study; Sy BT, Tong HV and Hoan NX performed the experiments; Song LH, Toan NL and Hoan NX are involved in patient recruitment; Bock CT and Velavan TP contributed to study materials and consumables; Hoan NX, Tong HV and Sy BT performed the statistical analyses and interpreted the data; Hoan NX, Sy BT, Tong HV, Meyer CG and Velavan TP wrote the manuscript; Sy BT, Hoan NX and Tong HV contributed equally to this work.
Supported by NAFOSTED, No. 108.02-2017.15; and BMBF, No. 01DP17047.
Institutional review board statement: The study was approved by the institutional review board of the 108 Military Central Hospital and the 103 Military Hospital of the Vietnam Military Medical University, Hanoi, Vietnam.
Informed consent statement: Informed written consent was obtained after explanation of the study at the time of sampling from all participants.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Thirumalaisamy P Velavan, PhD, Professor, Molecular Genetics of Infectious Diseases, Institute of Tropical Medicine, University of Tübingen, Wilhelmstrasse 27, Tübingen 72074, Germany. firstname.lastname@example.org
Telephone: +49-7071-2985981 Fax: +49-7071-294684
Received: October 16, 2017
Peer-review started: October 17, 2017
First decision: November 14, 2017
Revised: November 15, 2017
Accepted: November 28, 2017
Article in press: November 28, 2017
Published online: January 14, 2018