Published online Jan 14, 2018. doi: 10.3748/wjg.v24.i2.248
Peer-review started: October 17, 2017
First decision: November 14, 2017
Revised: November 15, 2017
Accepted: November 28, 2017
Article in press: November 28, 2017
Published online: January 14, 2018
Hepatitis B virus (HBV) infection is a major health concern in Vietnam. Investigations were carried out to determine IRF5 polymorphisms in the 3’ UTR region of the IFR5 locus on susceptibility to HBV infection and progression of liver diseases among clinically classified Vietnamese patients.
IRF5 is a particularly interesting member of the IRF family, which are crucial in the innate immune response with a variety of activities like activation of type I IFN genes, inflammatory cytokines and tumor suppressors. There are so far no data available on associations of IRF5 variants with susceptibility to HBV infection and the clinical course of HBV-related liver diseases.
This study aims to investigate possible effects of IRF5 polymorphisms on susceptibility to HBV infection and progression of liver diseases among clinically classified Vietnamese patients.
The four IRF5 SNPs rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714G/A located closely at the 3′ downstream regions of the IRF5 locus were selected for this study. IRF5 variant genotyping was performed by direct sanger sequencing and by application of TaqMan® SNP genotyping assays.
Three hundred seventy-nine unrelated Vietnamese HBV-infected patients were randomly recruited in a case-control design. IRF5 variants are associated with LC progression in patients with CHB while the constructed haplotypes are associated with LC and HCC progression in CHB patients. In addition, IRF5 variants and their constructed haplotypes are associated with clinical outcomes of HBV infection.
Host immune factors are crucial to the pathogenesis of HBV infection. For the first time the authors provide evidence of the functional role of human IRF5 in immune response to the clinical outcome of HBV infection. IRF5 variants rs13242262A/T and rs10488630A/G are associated with LC progression in patients with CHB. IRF5 haplotypes appear to influence the outcome of HBV infection.
Further studies in this direction will provide insights into a role of IRF5 variants as prognostic markers of HBV-related liver diseases.