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World J Gastroenterol. Feb 14, 2017; 23(6): 949-956
Published online Feb 14, 2017. doi: 10.3748/wjg.v23.i6.949
Lymphocytic esophagitis: Still an enigma a decade later
Carol Rouphael, Ilyssa O Gordon, Prashanthi N Thota
Carol Rouphael, Department of General Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Ilyssa O Gordon, Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Prashanthi N Thota, Department of Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Author contributions: All authors contributed to this paper with conception and design of the study, literature review and analysis, drafting, revision and final approval of the manuscript.
Conflict-of-interest statement: All authors have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Prashanthi N Thota, MD, FACG, Director, Esophageal Center, Department of Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States. thotap@ccf.org
Telephone: +1-216-4440780 Fax: +1-216-4454222
Received: October 24, 2016
Peer-review started: October 27, 2016
First decision: December 2, 2016
Revised: December 14, 2016
Accepted: January 18, 2017
Article in press: January 18, 2017
Published online: February 14, 2017
Core Tip

Core tip: Lymphocytic esophagitis has recently been described in 2006 and subsequently, multiple groups have attempted to describe its clinical associations and risk factors with minimal information available on treatment. We performed a PubMed search of all case reports and retrospective studies published in English about lymphocytic esophagitis. The objective of this paper is to present a scientific review of all aspects of this emerging clinical entity known to date.