Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2017; 23(5): 817-829
Published online Feb 7, 2017. doi: 10.3748/wjg.v23.i5.817
Dendritic cells engineered to secrete anti-DcR3 antibody augment cytotoxic T lymphocyte response against pancreatic cancer in vitro
Jiang Chen, Xiao-Zhong Guo, Hong-Yu Li, Jia-Jun Zhao, Wen-Da Xu
Jiang Chen, Xiao-Zhong Guo, Hong-Yu Li, Jia-Jun Zhao, Wen-Da Xu, Department of Gastroenterology, Shenyang General Hospital of PLA, Shenyang 110016, Liaoning Province, China
Author contributions: Chen J performed the majority of experiments and analyzed the data; Li HY and Zhao JJ performed the molecular investigations; Guo XZ designed and coordinated the research; Chen J and Xu WD wrote the paper.
Supported by National Natural Science Foundation of China, No. 81071982.
Institutional review board statement: This study was approved by the Ethics Committee of Shenyang General Hospital of PLA.
Institutional animal care and use committee statement: There was no animal experimentation in this study.
Conflict-of-interest statement: The authors have no conflict of interests to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiao-Zhong Guo, MD, Department of Gastroenterology, Shenyang General Hospital of PLA, No. 83 Wenhua Road, Shenyang 110016, Liaoning Province, China. guoxiaozhong1962@aliyun.com
Telephone: +86-24-28897603 Fax: +86-24-28851113
Received: September 13, 2016
Peer-review started: September 14, 2016
First decision: October 20, 2016
Revised: November 4, 2016
Accepted: December 21, 2016
Article in press: December 21, 2016
Published online: February 7, 2017
Core Tip

Core tip: Dendritic cells co-transfection with tumor-associated antigens RNA and humanized anti-DcR3 monoclonal antibody mRNA may augment cytotoxic T lymphocyte responses against pancreatic cancer in vitro. This finding lays a good foundation for further investigation of tumor dendritic cells’ vaccine targeting DcR3 protein against pancreatic cancer.