Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2016; 22(43): 9515-9524
Published online Nov 21, 2016. doi: 10.3748/wjg.v22.i43.9515
Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK
Ya-Jing Feng, Yong-Yu Li, Xu-Hong Lin, Kun Li, Ming-Hua Cao
Ya-Jing Feng, Yong-Yu Li, Xu-Hong Lin, Kun Li, Ming-Hua Cao, Department of Pathophysiology, Tongji University School of Medicine, Shanghai 200092, China,
Ya-Jing Feng, Department of Center ICU, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
Author contributions: Li YY designed the project; Feng YJ performed the experiments and analyzed the data; Lin XH, Li K and Cao MH contributed to performing the experiments and in data analysis; Feng YJ and Li YY wrote the paper.
Supported by the National Natural Science Foundation of China, No. 81400581 (to Feng YJ) and No. 81270477 (to Li YY).
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Department of Pathophysiology, Tongji University School of Medicine, China.
Institutional animal care and use committee statement: All experiments involving animals were reviewed and approved by the Animal Care and Use Committee of Tongji University (IACUC No. 2008-001).
Conflict-of-interest statement: We declare that the authors of this article do not have any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yong-Yu Li, MD, Department of Pathophysiology, Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China. liyongyu@tongji.edu.cn
Telephone: +86-21-65981021 Fax: +86-21-65987071
Received: June 22, 2016
Peer-review started: June 24, 2016
First decision: August 22, 2016
Revised: September 4, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: November 21, 2016
Core Tip

Core tip: Inflammatory bowel disease demands more effective therapies, and cannabinoids are beneficial in alleviating inflammation in some diseases. In this study, we reported the anti-inflammatory effect and protective role of WIN55-212-2, an agonist of cannabinoid receptors, on the mice with dextran sulfate sodium-induced experimental colitis, and revealed that this agent exerts its action at least partially by inhibiting p38 mitogen-activated protein kinase.