Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2016; 22(40): 8929-8939
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.8929
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.8929
Fecal microbiota in pouchitis and ulcerative colitis
Kai-Yu Li, Jiang-Peng Wei, Sen-Yang Gao, Ying-Ying Zhang, Li-Tian Wang, Gang Liu, Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China
Jian-Lin Wang, Department of General Surgery, Tianjin NanKai Hospital, Tianjin 300100, China
Author contributions: Li KY conceived and designed the study, acquired the data and contributed to final approval of the version of the article to be published; Wang JL performed the majority of the experiments and analyzed the data; Wei JP and Wang LT analyzed and interpreted the data; Wang JL drafted the manuscript; Gao SY and Zhang YY performed the statistical analysis and drafted the manuscript; Liu G revised the manuscript for important intellectual content, and supplied administrative, technical, and material support.
Supported by Academician Jie-Shou Li Intestinal Barrier Research Foundation , No. LJS_201008 .
Institutional review board statement: The study was reviewed and approved by Tianjin Medical University General Hospital Institutional Review Board, Tianjin 300052, China.
Conflict-of-interest statement: This work was presented as a poster at the 10th International Congress on Autoimmunity in Leipzig, Germany, April 6-10, 2016. We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gang Liu, MD, PhD, Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China. landmark1503@sina.com
Telephone: +86-22-60363901 Fax: +86-22-60362365
Received: June 24, 2016
Peer-review started: June 24, 2016
First decision: August 8, 2016
Revised: August 15, 2016
Accepted: August 30, 2016
Article in press: August 30, 2016
Published online: October 28, 2016
Peer-review started: June 24, 2016
First decision: August 8, 2016
Revised: August 15, 2016
Accepted: August 30, 2016
Article in press: August 30, 2016
Published online: October 28, 2016
Core Tip
Core tip: Dysbiosis in pouchitis might be similar to that observed in ulcerative colitis (UC). This study aimed to determine the altered microflora in patients with UC and pouchitis, and to investigate the relationship between them. We demonstrated the reduced biodiversity of the fecal microbiota in UC and pouchitis patients. The altered composition of the intestinal microbiota in UC and pouchitis included decreased numbers of two bacteria commonly observed in UC, and higher levels of Clostridium perfringens in both UC and pouchitis. The increase of this bacterium in feces suggested that it plays a role in exacerbating UC and pouchitis.