Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2016; 22(32): 7353-7364
Published online Aug 28, 2016. doi: 10.3748/wjg.v22.i32.7353
Effects of different diets on intestinal microbiota and nonalcoholic fatty liver disease development
Jian-Ping Liu, Wen-Li Zou, Shui-Jiao Chen, Hong-Yun Wei, Ya-Ni Yin, Yi-You Zou, Fang-Gen Lu
Jian-Ping Liu, Hong-Yun Wei, Fang-Gen Lu, Department of Gastroenterology, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
Wen-Li Zou, Department of Nephrology, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China
Shui-Jiao Chen, Ya-Ni Yin, Yi-You Zou, Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Author contributions: Yin YN, Zou YY and Lu FG designed the research; Liu JP, Zou WL and Chen SJ performed the research; Liu JP and Zou WL analyzed and interpreted the data; Liu JP, Wei HY and Yin YN wrote the paper.
Supported by National Natural Science Foundation of China, No. 81300270.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Central South University, Changsha, China.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: Raw sequencing data are available from the corresponding author at Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Ya-Ni Yin, MD, PhD, Department of Gastroenterology, Xiangya Hospital of Central South University, No. 87, Xiangya Road, Changsha 410008, Hunan Province, China.
Telephone: +86-731-84327106 Fax: +86-731-84327332
Received: April 7, 2016
Peer-review started: April 8, 2016
First decision: May 12, 2016
Revised: June 9, 2016
Accepted: July 21, 2016
Article in press: July 21, 2016
Published online: August 28, 2016
Core Tip

Core tip: Diet plays an important role in development of nonalcoholic fatty liver disease (NAFLD), and can shape intestinal microbiota, which is closely linked to NAFLD. We studied the effects of high-fat, high-sugar and high-protein diets on intestinal microbiota and NAFLD development in an isocaloric way. NAFLD-inducing effects of high-fat and high-sugar diets, compared with high-protein diet, are independent from calories, and these diets can alter intestinal microbiota independently from calories. The effects of these diets on NAFLD development at the same caloric intake may be associated with changes in intestinal microbiota. These findings are meaningful for appropriate dietary therapy for NAFLD.